{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:23:21Z","timestamp":1789986201534,"version":"4.0.1"},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,12,6]],"date-time":"2016-12-06T00:00:00Z","timestamp":1480982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of the present study was to provide first\u2010hand information about the prevalence of mild cognitive impairment (MCI) and Alzheimer's disease (AD) in Tamil Nadu, a southern state in India, and examine if there exists a relationship between cognitive functions and biochemical parameters in these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Surveys were collected from adults, older men and women (<jats:italic>n<\/jats:italic>\u00a0=\u00a03126) from different regions of Tamil Nadu, which were followed up after 12\u00a0months for 1337 participants. Mini\u2010Mental State Examination (MMSE) scores, lipid profile, and liver function tests were carried out in the elderly, MCI and AD patients. Based on the MMSE scores, the elderly population was classified into old control (28.97\u00a0\u00b1\u00a01.49;<jats:italic>n<\/jats:italic>\u00a0=\u00a01868), MCI (19.58\u00a0\u00b1\u00a01.17;<jats:italic>n<\/jats:italic>\u00a0=\u00a0734) and AD (7.18\u00a0\u00b1\u00a01.38;<jats:italic>n<\/jats:italic>\u00a0=\u00a0304) groups. Peripheral blood samples were collected after overnight fast from both male and female volunteers (<jats:italic>n<\/jats:italic>\u00a0=\u00a040 per group) who were categorized as young adult control, old control, MCI and AD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>AD patients showed lower MMSE scores compared with the young adults, old and MCI groups, and MMSE further decreased at follow\u2010up examination a year later. In the serum of AD patients, high\u2010density lipoprotein, alkaline phosphatase activity and bilirubin levels were lower, whereas low\u2010density lipoprotein, total cholesterol and triglycerides levels were higher. MMSE was positively correlated with high\u2010density lipoprotein, and negatively correlated with other lipid parameters in AD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Hypercholesterolemia is a risk factor for AD that might result in neurotoxicity and cognitive impairment. Dysfunction of lipoprotein and heme metabolism might also provide additional targets for AD diagnosis.<jats:bold>Geriatr Gerontol Int 2017; 17: 1737\u20131745.<\/jats:bold><\/jats:p><\/jats:sec>","DOI":"10.1111\/ggi.12957","type":"journal-article","created":{"date-parts":[[2016,12,6]],"date-time":"2016-12-06T06:13:06Z","timestamp":1481004786000},"page":"1737-1745","source":"Crossref","is-referenced-by-count":25,"title":["Interrelationship between Mini\u2010Mental State Examination scores and biochemical parameters in patients with mild cognitive impairment and Alzheimer's disease"],"prefix":"10.1111","volume":"17","author":[{"given":"Ramasamy","family":"Vasantharekha","sequence":"first","affiliation":[{"name":"Integrative Medicine Laboratory, Department of Biotechnology SRM University Kattankulathur Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah P.","family":"Priyanka","sequence":"additional","affiliation":[{"name":"Integrative Medicine 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