{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:38:07Z","timestamp":1792175887833,"version":"4.4.0"},"reference-count":38,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2017,4,24]],"date-time":"2017-04-24T00:00:00Z","timestamp":1492992000000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To develop experimental multi\u2010domain interventions for older people with mild\u2010to\u2010moderate dementia, and to evaluate the effect of delaying cognitive and physical decline, and improvement or prevention of geriatric syndromes during 1\u2010year follow up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants aged 65\u00a0years and older with mild\u2010to\u2010moderate dementia (clinical dementia rating [CDR] 1 or 2) were grouped as intervention in Jia\u2010Li Veterans Home and usual care model in the community (Memory clinic). All residents in Jia\u2010Li Veterans Home received comprehensive intervention, including Multi\u2010disciplinary team consultation and intervention, Multi\u2010component non\u2010pharmacological management, geriatric syndromes survey and intervention by CGA, and a dementia friendly medical Green channel Approach (2MCGA). The decline of cognitive and physical function are determined by the change of Mini\u2010Mental State Examination score, CDR and the sum of CDR box, as well as activities of daily living based on the Barthel Index. We also screened geriatric syndromes at baseline and 1\u00a0year later.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Participants in the intervention group were older and had a lower educational level, lower body mass index, poor baseline activities of daily living function, lower visual impairment, and higher rates of hearing impairment, polypharmacy and risk of malnutrition. The residents receiving 2MCGA had lower baseline Mini\u2010Mental State Examination scores, and higher CDR. For residents in Jia\u2010Li Veterans Home, all cognitive measurements except Mini\u2010Mental State Examination were significantly associated with delaying the decline of cognition after analyzing by multiple linear regression, and multivariate logistic regression also showed that patients living in the community was independently associated with a higher odds ratio for activities of daily living decline (3.180, 95% CI 1.384\u20137.308, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.006). There are also more improvement in their baseline geriatric syndromes and suffered less from new geriatric syndromes, including falls, urinary incontinence, and risk of malnutrition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The 2MCGA intervention shows strong delays in the decline of cognition and physical function for older residents with mild\u2010to\u2010moderate dementia. Furthermore, this strategy can also improve or prevent the onset of new geriatric syndromes, especially fall episodes, urinary incontinence and risk of malnutrition. <jats:bold>Geriatr Gerontol Int 2017; 17 (Suppl. 1): 36\u201343<\/jats:bold>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ggi.13035","type":"journal-article","created":{"date-parts":[[2017,4,24]],"date-time":"2017-04-24T08:38:19Z","timestamp":1493023099000},"page":"36-43","source":"Crossref","is-referenced-by-count":13,"title":["Delaying cognitive and physical decline through multidomain interventions for residents with mild\u2010to\u2010moderate dementia in dementia care units in Taiwan: A prospective cohort study"],"prefix":"10.1111","volume":"17","author":[{"given":"Chih\u2010Kuang","family":"Liang","sequence":"first","affiliation":[{"name":"Center for Geriatrics and Gerontology Kaohsiung Veterans General Hospital  Kaohsiung Taiwan"},{"name":"Division of Neurology, Department of Internal Medicine Kaohsiung Veterans General Hospital  Kaohsiung Taiwan"},{"name":"Aging and Health Research Center National Yang Ming University  Taipei Taiwan"},{"name":"Institute of Environmental and Occupational Health Sciences, School of Medicine National Yang\u2010Ming University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Yueh","family":"Chou","sequence":"additional","affiliation":[{"name":"Center for Geriatrics and Gerontology Kaohsiung Veterans General Hospital  Kaohsiung Taiwan"},{"name":"Aging and Health Research Center National Yang Ming University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang\u2010Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Aging and Health Research Center National Yang Ming University  Taipei Taiwan"},{"name":"Center for Geriatrics and Gerontology Taipei Veterans General Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuei\u2010Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"JiaLi Veterans Home Veterans Affairs Council  Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih\u2010Yi","family":"Lin","sequence":"additional","affiliation":[{"name":"Center for Geriatrics and Gerontology Taichung Veterans General Hospital  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang\u2010Kung","family":"Chen","sequence":"additional","affiliation":[{"name":"Aging and Health Research Center National Yang Ming University  Taipei Taiwan"},{"name":"Center for Geriatrics and Gerontology Taipei Veterans General Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Te","family":"Lin","sequence":"additional","affiliation":[{"name":"Center for Geriatrics and Gerontology Kaohsiung Veterans General Hospital  Kaohsiung Taiwan"},{"name":"Division of Neurology, Department of Internal Medicine Kaohsiung Veterans General Hospital  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsung\u2010Yun","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Environmental and Occupational Health Sciences, School of Medicine National Yang\u2010Ming University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching\u2010Hui","family":"Loh","sequence":"additional","affiliation":[{"name":"Department of Healthcare and Medical care Veterans Affairs Council  Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-014082"},{"key":"e_1_2_7_3_1","volume-title":"U.S. Preventive Services Task Force Evidence Syntheses, formerly Systematic Evidence Reviews. 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