{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:28:17Z","timestamp":1762867697592,"version":"3.40.5"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T00:00:00Z","timestamp":1546905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Neutrophil extracellular traps play key roles in the necrotizing vasculitis associated with anti\u2010neutrophil cytoplasmic antibody\u2010associated vasculitis (AAV). However, the relationships between neutrophil extracellular traps formation and the distribution and phase of vasculitis are not well understood. In the present study, we clarified the clinicopathological characteristics of older AAV patients, as well as the expression of citrullinated histone H3 (citH3), a marker of neutrophil extracellular traps, in autopsied AAV patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed autopsy cases that were carried out at Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan, from 2001 to 2018. The expression of citH3 was determined by immunostaining.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>AAV patients (six cases) were elderly (aged 73\u201394 years; three men and three women; myeloperoxidase anti\u2010neutrophil cytoplasmic antibody\u2010positive, five cases; proteinase\u20103 anti\u2010neutrophil cytoplasmic antibody\u2010positive, one case; disease duration was 1.5\u20135.5 months; and patients were treated with steroids. All patients had necrotizing vasculitis in the medium\u2010to\u2010small\u2010sized vessels in various organs, and also severe vasculitis\u2010associated lesions including brain hemorrhage, alveolar bleeding, interstitial pneumonia, crescentic nephritis, acute pancreatitis and gastrointestinal bleeding. Expression of citH3 was associated with the activity of inflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We report severe clinicopathological characteristics of AAV in older patients. Expression of citH3 was a useful marker to evaluate vasculitis severity. Identification of these features might aid in the diagnosis of AAV. <jats:bold>Geriatr Gerontol Int 2019; 19: 259\u2013264<\/jats:bold>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ggi.13596","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T08:23:29Z","timestamp":1547022209000},"page":"259-264","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Citrullinated histone H3 expression in anti\u2010neutrophil cytoplasmic antibody\u2010associated vasculitis in older Japanese autopsy patients"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3235-655X","authenticated-orcid":false,"given":"Yoko","family":"Matsuda","sequence":"first","affiliation":[{"name":"Department of Pathology Tokyo Metropolitan Geriatric Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuyo","family":"Itabashi","sequence":"additional","affiliation":[{"name":"Department of Nephrology Tokyo Metropolitan Geriatric Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuko","family":"Tachibana","sequence":"additional","affiliation":[{"name":"Department of Nephrology Tokyo Metropolitan Geriatric Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiko","family":"Sugihara","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Tokyo Metropolitan Geriatric Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Sakashita","sequence":"additional","affiliation":[{"name":"Department of Neuropathology (Brain Bank for Aging Research) Tokyo Metropolitan Geriatric Hospital &amp; Institute of Gerontology  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyasu","family":"Matsubara","sequence":"additional","affiliation":[{"name":"Department of Neuropathology (Brain Bank for Aging Research) Tokyo Metropolitan Geriatric Hospital &amp; Institute of Gerontology  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeo","family":"Murayama","sequence":"additional","affiliation":[{"name":"Department of Neuropathology (Brain Bank for Aging Research) Tokyo Metropolitan Geriatric Hospital &amp; Institute of Gerontology  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wako","family":"Yumura","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Preventive Medical Center International University of Health Welfare Hospital  Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Analytic Human Pathology Nippon Medical School  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Takei","sequence":"additional","affiliation":[{"name":"Department of Nephrology Tokyo Metropolitan Geriatric Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomio","family":"Arai","sequence":"additional","affiliation":[{"name":"Department of Pathology Tokyo Metropolitan Geriatric Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.37715"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.062711"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfn354"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2009.090533"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-014-0435-7"},{"key":"e_1_2_7_7_1","first-page":"1615","article-title":"ANCA\u2010associated small\u2010vessel vasculitis","volume":"65","author":"Mansi IA","year":"2002","journal-title":"Am Fam Physician"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69114-9"},{"key":"e_1_2_7_9_1","first-page":"671","article-title":"ANCA\u2010associated vasculitis\u2010\u2010an autopsy study","volume":"112","author":"Rott T","year":"2000","journal-title":"Wien Klin Wochenschr"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2014.103"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1959"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2012.00380"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2012.00333"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/pin.12434"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-017-3546-4"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013060606"},{"key":"e_1_2_7_17_1","first-page":"149","article-title":"Possible linkage between microscopic polyangiitis and thrombosis via neutrophil extracellular traps","volume":"32","author":"Imamoto T","year":"2014","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/nep.12736"}],"container-title":["Geriatrics &amp; 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