{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T17:25:04Z","timestamp":1789233904078,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,2,25]],"date-time":"2019-02-25T00:00:00Z","timestamp":1551052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005928","name":"Daiwa Securities Health Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005928","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001697","name":"Keio University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001697","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Few cohort studies targeting the oldest\u2010old individuals have been carried out. The subiculum in the hippocampus is thought to be related to memory function, and atrophy of this structure might result in the conversion from amnestic mild cognitive impairment to Alzheimer's disease. Thus, we sought to examine the relationship between subiculum volumes and memory function in individuals aged \u226595\u2009years, using a novel cognitive examination called the Addenbrooke's Cognitive Examination\u2009III (ACE\u2010III) and an advanced magnetic resonance imaging analytical method, Multiple Automatically Generated Templates Brain Segmentation Algorithm (MAGeTbrain), to measure hippocampal subfield volumes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A part of the cohort data of the Arakawa 95+ study for the oldest\u2010old aged \u226595\u2009years was used. A total of 10 individuals completed all of the examinations. The MAGeT brain was applied to estimate the subfield volumes of the hippocampus. Correlation analyses and multiple regression analyses were carried out to examine a relationship among ACE\u2010III memory scores and the subfield volumes in the hippocampus, including the subiculum.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a significant relationship between ACE\u2010III memory scores and subdivision volumes. Regression analyses showed that subiculum volumes were associated with ACE\u2010III memory scores in the oldest\u2010old individuals (\u03b2\u2009=\u20090.721, <jats:italic>P<\/jats:italic> =\u20090.019; <jats:italic>F<\/jats:italic><jats:sub>1, 8<\/jats:sub> =\u20098.67, adjusted <jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> =\u20090.46).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The subiculum might play a pivotal role in memory function in the oldest\u2010old individuals aged \u226595\u2009years. The present finding warrants further research including larger sample sizes. <jats:bold>Geriatr Gerontol Int 2019; 19: 347\u2013351<\/jats:bold>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ggi.13614","type":"journal-article","created":{"date-parts":[[2019,2,26]],"date-time":"2019-02-26T06:53:15Z","timestamp":1551163995000},"page":"347-351","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Subiculum volumes associated with memory function in the oldest\u2010old individuals aged 95\u2009years and older"],"prefix":"10.1111","volume":"19","author":[{"given":"Yoko","family":"Eguchi","sequence":"first","affiliation":[{"name":"Department of Neuropsychiatry Keio University School of Medicine  Tokyo Japan"},{"name":"Department of Nuclear Medicine Saitama Medical University International Medical Center  Saitama 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