{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T22:33:40Z","timestamp":1781994820802,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,2,20]],"date-time":"2019-02-20T00:00:00Z","timestamp":1550620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102017R1D1A1B03029140"],"award-info":[{"award-number":["NRF\u20102017R1D1A1B03029140"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of the present study was to investigate the clinical outcomes of kidney transplantation (KT) in elderly recipients compared with those in young recipients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We compared the incidence of biopsy\u2010proven acute rejection, death\u2010censored allograft survival and all\u2010cause mortality, and also compared the impact of high sensitization or desensitization on the clinical outcomes of elderly and young recipients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 4966 KT recipients from the Korean Organ Transplantation Registry were included. The definition of elderly recipients was based on age &gt;60\u2009years (<jats:italic>n<\/jats:italic>\u2009=\u2009356), and recipients aged &lt;60\u2009years were defined as young recipients (<jats:italic>n<\/jats:italic>\u2009=\u20094610). The incidence of biopsy\u2010proven acute rejection did not differ between the two groups irrespective of the donor type; however, the impact of high sensitization was significant only in young recipients. Being an elderly recipient was an independent risk factor for death\u2010censored allograft failure in terms of overall and living donor KT, but not with deceased donor KT. In regard to patient death, being an elderly recipient was a significant predictor in general and in the two subgroups, and desensitization showed a significant interaction with death in the elderly recipients in the living donor KT group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In conclusion, KT in elderly recipients might be associated with poor allograft or patient survival in general, and especially, desensitization therapy carried out in these patients might increase the risk of patient mortality. <jats:bold>Geriatr Gerontol Int 2019; 19: 392\u2013398<\/jats:bold>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ggi.13630","type":"journal-article","created":{"date-parts":[[2019,2,21]],"date-time":"2019-02-21T02:46:51Z","timestamp":1550717211000},"page":"392-398","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Clinical outcomes of kidney transplantation in older end\u2010stage renal disease patients: A nationwide cohort study"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5604-1296","authenticated-orcid":false,"given":"Eun Jeong","family":"Ko","sequence":"first","affiliation":[{"name":"Transplantation Research Center, Division of Nephrology, Department of Internal Medicine Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaeseok","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Transplantation Center Seoul National University Hospital  Jongno Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Curie","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Transplantation Center Seoul National University Hospital  Jongno Korea"},{"name":"Department of Internal Medicine\u2010Nephrology Seoul National University Hospital  Jongno Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myoung Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery\u2010Transplantation Severance Hospital  Seodaemun Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duck Jong","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Surgery\u2010Transplantation Asan Medical Center, University of Ulsan College of Medicine  Songpa Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Joo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery\u2010Transplantation Samsung Medical Center  Gangnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chul Woo","family":"Yang","sequence":"additional","affiliation":[{"name":"Transplantation Research Center, Division of Nephrology, Department of Internal Medicine Seoul St. Mary's Hospital, College of Medicine, The Catholic University 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