{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T20:47:06Z","timestamp":1778186826359,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T00:00:00Z","timestamp":1552348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013170","name":"Ono Pharmaceutical","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013170","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Most patients with Alzheimer's disease (AD) experience poor food intake and\/or loss of appetite, which accelerates cognitive impairment. Several reports have shown that rivastigmine improves appetite in AD patients. The present study investigated the efficacy of a rivastigmine transdermal patch for the treatment of low food intake in AD patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>AD patients, recruited through the Attitude Towards Food Consumption in Alzheimer's Disease Patients Revive with Rivastigmine Effects study, were recognized as experiencing either a loss of appetite or poor food intake. A rivastigmine transdermal patch was administered to study participants for 16\u2009weeks. Patients\u2019 food intake, bodyweight, Mini\u2010Mental State Examination scores and any adverse events were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 38 patients with AD (age 86.2\u2009\u00b1\u20095.4\u2009years) were examined. Their mean Mini\u2010Mental State Examination score was 10.1\u2009\u00b1\u20097.0 at baseline. A significant increase in food intake amount (54.9\u2009\u00b1\u200998.0\u2009g, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) and food intake ratio (9.3%\u2009\u00b1\u200917.6%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) was observed by week\u20091, improvements that were maintained throughout the study duration. A multiple linear regression analysis showed that no independent variables were significantly associated with changes in food intake amount or ratio. Patients in the higher Mini\u2010Mental State Examination subgroup showed a trend change in food intake amount, although this did not reach statistical significance (<jats:italic>P<\/jats:italic>\u2009=\u20090.07).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present study suggests that a rivastigmine transdermal patch might improve poor food intake or loss of appetite in patients with AD. <jats:bold>Geriatr Gerontol Int 2019; 19: 571\u2013576<\/jats:bold>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ggi.13644","type":"journal-article","created":{"date-parts":[[2019,3,13]],"date-time":"2019-03-13T02:50:10Z","timestamp":1552445410000},"page":"571-576","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Efficacy of rivastigmine transdermal therapy on low food intake in patients with Alzheimer's disease: The Attitude Towards Food Consumption in Alzheimer's Disease Patients Revive with 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