{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T20:00:53Z","timestamp":1765742453049,"version":"3.40.5"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T00:00:00Z","timestamp":1553472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research","award":["18 K173457"],"award-info":[{"award-number":["18 K173457"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Limited information is available on the prevalence of drug\u2013drug interactions (DDI) in residents of long\u2010term care facilities who often receive multiple drugs. This study aimed to evaluate the prevalence of clinically relevant cytochrome P450\u2010mediated potential DDI in residents of intermediate care facilities for older adults (called <jats:italic>Roken<\/jats:italic>) in Japan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A nationwide drug utilization study was carried out for <jats:italic>Roken<\/jats:italic> residents in 2015 (up to five residents per facility). Potential DDI were identified with an explicit list of drugs that can be involved in clinically relevant cytochrome P450\u2010mediated DDI in Japan. Logistic regression was used to evaluate the association of the number of drugs prescribed with the presence of potential DDI, adjusted for age, sex and long\u2010term care needs level.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 1222 residents of 348 <jats:italic>Roken<\/jats:italic> who were prescribed two or more active drug substances. The participants who received \u22656 and\u2009\u226510 drugs represented 49% and 10% of total participants, respectively. In total, 42 two\u2010drug combinations involving potential DDI were identified in 33 participants (2.7%) \u2013 benzodiazepines, proton pump inhibitors, calcium channel blockers and anti\u2010epileptic drugs were frequently involved. The adjusted odds ratios for potential DDI were 2.84 (95% confidence interval 1.15\u20137.02) or 7.82 (95% confidence interval 2.96\u201320.70) in residents receiving six to nine drugs or\u2009\u226510 drugs, compared with those receiving two to five drugs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Approximately 3% of <jats:italic>Roken<\/jats:italic> residents were at risk for clinically relevant DDI. Reducing the number of drugs prescribed through medication reviews would mitigate the potential risk. <jats:bold>Geriatr Gerontol Int 2019; 19: 513\u2013517<\/jats:bold>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ggi.13652","type":"journal-article","created":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T06:19:57Z","timestamp":1553581197000},"page":"513-517","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Prevalence of cytochrome P450\u2010mediated potential drug\u2013drug interactions in residents of intermediate care facilities for older adults in Japan"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4939-1834","authenticated-orcid":false,"given":"Shota","family":"Hamada","sequence":"first","affiliation":[{"name":"Research Department Institute for Health Economics and Policy, Association for Health Economics Research and Social Insurance and Welfare  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyuki","family":"Ohno","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The University of Tokyo Hospital, Faculty of Medicine, The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taro","family":"Kojima","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiro","family":"Okochi","sequence":"additional","affiliation":[{"name":"Tatsumanosato Geriatric Health Services Facility  Daito Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Akishita","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,3,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60240-2"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h949"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2007.06.007"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-013-9811-y"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1R621"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200730100-00009"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpt.12502"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.9.1107"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.13.1652"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61092-7"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-015-0318-1"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph14121489"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2015.03.003"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2016.06.011"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.2165\/11534320-000000000-00000"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/02813430600991980"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.2232"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002512-200825080-00005"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/02813432.2016.1207142"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.2055-2335.2012.tb00128.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpt.12163"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/ggi.12890"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/ggi.12761"},{"key":"e_1_2_7_25_1","unstructured":"HisakaA OhnoY SuzukiH MaedaK SugiyamaY.Drugs involved in significant pharmacokinetic drug\u2010drug interactions in 2016. 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