{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T10:27:27Z","timestamp":1773656847704,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T00:00:00Z","timestamp":1562025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>We investigated the long\u2010term risk of dementia for up to 10\u2009years in patients with stroke and broadened the correlates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We carried out a case\u2013control study using the Taiwan National Health Insurance Research database in 2000 with a sampled population of 1\u2009million. The study cohort comprised 8236 patients with stroke and no dementia history. We carried out a 1:1 case\u2013control matched analysis on estimated propensity scores. Cox proportional hazards regressions were carried out to estimate the risk of dementia during the 5\u2010 and 10\u2010year follow\u2010up periods. The risk factors were also investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The stroke cohort was significantly at more risk of dementia during the 5\u2010 and 10\u2010year follow\u2010up periods, with adjusted hazard ratios 1.87 and 1.53, respectively. The patients with ischemic stroke, transient ischemic attack and intracerebral hemorrhage had a significantly higher risk of dementia after 5 and 10\u2009years, with adjusted hazard ratios of 1.81 and 1.49, 1.92 and 1.61, and 2.14 and 1.61, respectively. The significant risk factors of dementia were age \u226560\u2009years, resident in southern and eastern regions, having low insurance range, and antiplatelet use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Stroke and the subtypes, including ischemic stroke, transient ischemic attack and intracerebral hemorrhage, increase the long\u2010term risk of dementia. The incidence of post\u2010stroke dementia increases yearly, but the relative risk decreases gradually. Older adults, residents in southern and eastern regions, having low insurance range and antiplatelet use were prominent risk factors of post\u2010stroke dementia in Taiwan. Careful management of stroke and risk factors of post\u2010stroke dementia with long\u2010term follow up of cognition should be reinforced. <jats:bold>Geriatr Gerontol Int 2019; 19: 815\u2013822<\/jats:bold>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ggi.13725","type":"journal-article","created":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T04:15:05Z","timestamp":1562127305000},"page":"815-822","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Factors of post\u2010stroke dementia: A nationwide cohort study in Taiwan"],"prefix":"10.1111","volume":"19","author":[{"given":"Chien\u2010Hsun","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurology Kaohsiung Municipal Hsiao\u2010Kang Hospital, Kaohsiung Medical University  Kaohsiung City Taiwan"},{"name":"Department of Neurology Kaohsiung Medical University Hospital, Kaohsiung Medical University  Kaohsiung City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Han","family":"Chang","sequence":"additional","affiliation":[{"name":"Center of Teaching and Research Kaohsiung Municipal Hsiao\u2010Kang Hospital, Kaohsiung Medical University  Kaohsiung City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei\u2010Chuan","family":"Chou","sequence":"additional","affiliation":[{"name":"Department of Neurology Kaohsiung Medical University Hospital, Kaohsiung Medical University  Kaohsiung City Taiwan"},{"name":"Graduate Institute of Clinical Medicine, College of Medicine Kaohsiung Medical University  Kaohsiung City Taiwan"},{"name":"Department of Neurology, Kaohsiung Municipal Ta\u2010Tung Hospital Kaohsiung Medical University  Kaohsiung City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun\u2010Hung","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology Kaohsiung Municipal Hsiao\u2010Kang 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