{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:30:50Z","timestamp":1762507850909,"version":"3.40.5"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T00:00:00Z","timestamp":1567555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>It is important to consider hypoglycemia for glycemic control in elderly patients with type 2 diabetes. Continuous blood glucose monitoring system is an effective method to investigate blood glucose fluctuation. This study examined hypoglycemia frequency using continuous blood glucose monitoring system in older patients with type\u20092 diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 70 patients with type\u20092 diabetes aged &gt;65\u2009years, receiving oral treatment only and having a glycated hemoglobin (HbA1c) level of &lt;8% were enrolled. Flash glucose monitoring system was used for the device. Patients were classified into three groups according to the type of medicine administered, in addition to other oral hypoglycemics, and were compared: (i) those taking sulfonylureas (SU); (ii) those taking glinides; and (iii) those who did not take either SU or glinides.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a significant positive correlation between the coefficient of variation and hypoglycemic frequency in all the patients, and a significant negative correlation between HbA1c and hypoglycemia in those receiving SU. When hypoglycemia was defined as glucose levels &lt;54\u2009mg\/dL and &lt;70\u2009mg\/dL, the cut\u2010off HbA1c values for developing hypoglycemia were 6.3% and 6.7%, sensitivity was 75.0% and 76.2%, and specificity was 90.9% and 77.6%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In older patients with type\u20092 diabetes receiving SU, hypoglycemic frequency increases with decreases in HbA1c level. In particular, in patients with HbA1c levels of &lt;6.3% receiving SU, it is necessary to consider medication modification. <jats:bold>Geriatr Gerontol Int 2019; 19: 1030\u20131035<\/jats:bold>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ggi.13765","type":"journal-article","created":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T06:48:46Z","timestamp":1567666126000},"page":"1030-1035","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Assessing hypoglycemia frequency using flash glucose monitoring in older Japanese patients with type\u20092 diabetes receiving oral hypoglycemic agents"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2940-8064","authenticated-orcid":false,"given":"Hironori","family":"Abe","sequence":"first","affiliation":[{"name":"Department of Diabetes, Metabolism, Endocrinology, Rheumatology and Collagen Diseases Tokyo Medical University  Tokyo 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