{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T11:16:30Z","timestamp":1781781390939,"version":"3.54.5"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,10,27]],"date-time":"2019-10-27T00:00:00Z","timestamp":1572134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["18he1402003"],"award-info":[{"award-number":["18he1402003"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>This prospective study investigated the additional utility of combining multiple imaging modalities with the Mini\u2010Mental State Examination (MMSE) in discriminating individuals with mild cognitive impairment (MCI) from cognitively normal individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 103 individuals with amnestic MCI and normal cognitive function were recruited from outpatients; they underwent examination using the MMSE, magnetic resonance imaging, <jats:sup>18<\/jats:sup>F\u2010fluorodeoxyglucose positron emission tomography and <jats:sup>11<\/jats:sup>C\u2010Pittsburgh compound\u2009B positron emission tomography. Binary logistic regression with receiver operator characteristic analysis was used to assess the combination of the abovementioned single or multiple imaging modalities with the MMSE. Eight models were constructed, and their area under the curve values and misclassification rates in discriminating individuals with amnestic MCI from cognitively normal individuals were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The addition of each of the imaging modalities improved the discrimination accuracy over that of the MMSE alone; the accuracy obtained with the addition of <jats:sup>18<\/jats:sup>F\u2010fluorodeoxyglucose positron emission tomography was the highest. The best model with the highest accuracy included a combination of all the imaging modalities in addition to the MMSE (area under the curve value 0.902).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The combination of all the imaging modalities in addition to the MMSE could facilitate more accurate diagnosis of amnestic MCI. Of the individual imaging modalities, the highest accuracy resulted from the addition of <jats:sup>18<\/jats:sup>F\u2010fluorodeoxyglucose positron emission tomography to the MMSE. <jats:bold>Geriatr Gerontol Int 2019; 19: 1193\u20131197<\/jats:bold>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ggi.13789","type":"journal-article","created":{"date-parts":[[2019,10,28]],"date-time":"2019-10-28T05:43:31Z","timestamp":1572241411000},"page":"1193-1197","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Diagnosis of mild cognitive impairment using multiple neuroimaging modalities in addition to the Mini\u2010Mental State Examination"],"prefix":"10.1111","volume":"19","author":[{"given":"Hiromi","family":"Kaneko","sequence":"first","affiliation":[{"name":"Department of Neurology Oita University, Faculty of Medicine  Oita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7137-7268","authenticated-orcid":false,"given":"Noriyuki","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Neurology Oita University, Faculty of Medicine  Oita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saho","family":"Nojima","sequence":"additional","affiliation":[{"name":"Department of Neurology Oita University, Faculty of Medicine  Oita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanako","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Neurology Oita University, Faculty of Medicine  Oita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Aso","sequence":"additional","affiliation":[{"name":"Department of Neurology Oita University, Faculty of Medicine  Oita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etsuro","family":"Matsubara","sequence":"additional","affiliation":[{"name":"Department of Neurology Oita University, Faculty of Medicine  Oita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.56.3.303"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2008.04.014"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(02)00002-9"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1208"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000150"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70291-0"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70090-0"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000110111"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.11.2412-a"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12149-012-0605-4"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ggi.12991"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2017.06.018"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00569-X"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1998.0395"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0193(1999)8:4<272::AID-HBM10>3.0.CO;2-4"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-014-9291-2"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-011-9136-1"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.244"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000487801"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-005-0050-x"},{"key":"e_1_2_7_23_1","first-page":"1778","article-title":"Hypometabolism exceeds atrophy in presymptomatic early\u2010onset familial Alzheimer's disease","volume":"47","author":"Mosconi L","year":"2006","journal-title":"J Nucl Med"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.63.5.674"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2004.01388.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-151010"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2017.07.003"}],"container-title":["Geriatrics &amp; 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