{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T14:34:41Z","timestamp":1771338881055,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T00:00:00Z","timestamp":1572480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>We examined the association of muscle mass and muscle strength with insulin resistance, focusing on lower limb muscles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a cross\u2010sectional study, and participants were registered in 2017 from the Tanno\u2010Sobetsu Study, a population\u2010based cohort study. After excluding individuals aged &lt;64\u2009years or with a history of diabetes mellitus, 272 non\u2010diabetic older adults (116 men, 156 women) met the inclusion criteria. According to the homeostasis model assessment of insulin resistance, the participants were divided into two groups; that is, the insulin resistance group (homeostasis model assessment of insulin resistance \u22651.73) and non\u2010insulin resistance group (homeostasis model assessment of insulin resistance &lt;1.73). Muscle mass (lower limb, upper limb, appendicular and trunk) and muscle strength (grip strength and knee extension torque) were measured and divided by the weight, and then multiplied by 100 to calculate the weight ratio (%). The adjusted odds ratio (OR) of each muscle index for risk of insulin resistance was calculated separately for both men and women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Lower limb muscle mass (OR 0.72, 95% CI 0.55\u20130.92 in men; OR 0.69, 95% CI 0.51\u20130.96 in women, respectively) and appendicular muscle mass (OR 0.75, 95% CI 0.61\u20130.94 in men; OR 0.72, 95% CI 0.54\u20130.95 in women, respectively), but not other muscle indexes, were associated with risk of insulin resistance, after adjusting for age, body mass index, highly sensitive C\u2010reacting protein and smoking habits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Lower limb muscle mass of non\u2010diabetic older adults is independently related to insulin resistance. <jats:bold>Geriatr Gerontol Int 2019; 19: 1254\u20131259<\/jats:bold>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ggi.13805","type":"journal-article","created":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T05:49:33Z","timestamp":1572587373000},"page":"1254-1259","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Lower limb muscle mass is associated with insulin resistance more than lower limb muscle strength in non\u2010diabetic older adults"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5733-9919","authenticated-orcid":false,"given":"Toshiaki","family":"Seko","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Hokkaido Chitose College of Rehabilitation  Chitose Japan"},{"name":"Department of Public Health Sapporo Medical University School of Medicine  Sapporo 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