{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:31:53Z","timestamp":1767918713167,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T00:00:00Z","timestamp":1578614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770773"],"award-info":[{"award-number":["81770773"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20171499"],"award-info":[{"award-number":["BK20171499"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>This cross\u2010sectional study aimed to investigate the differences in \u03b2\u2010cell function and insulin sensitivity between newly diagnosed aged and middle\u2010aged type\u20092 diabetes mellitus (T2DM) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 206 newly diagnosed T2DM patients aged \u226560\u2009years (A\u2010DM group) and 206 newly diagnosed sex\u2010 and glycated hemoglobin\u2010matched T2DM patients aged &lt;60\u2009years (MA\u2010DM group) were recruited. All patients underwent the 75\u2010g oral glucose tolerance test. Plasma glucose, lipid profiles, liver and renal function, glycated hemoglobin, and insulin were measured. Homeostasis model assessment for insulin resistance, quantitative insulin sensitivity check index, area under the curve of glucose during 0\u201330\u2009min (GluAUC30)\u2009\u00d7\u2009area under the curve of insulin during 0\u201330\u2009min (InsAUC30) and \u03b2\u2010cell function indexes were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age of the total 412 patients (356 men and 56 women) was 59.76\u2009\u00b1\u200913.32\u2009years. There were no significant differences in GluAUC120 between the two groups (106.89\u2009\u00b1\u200927.70 in A\u2010DM <jats:italic>vs<\/jats:italic> 108.32\u2009\u00b1\u200927.58 in MA\u2010DM; <jats:italic>P<\/jats:italic> = 0.6), but \u0394I30\/\u0394G30, InsAUC30 and GluAUC30\u2009\u00d7\u2009InsAUC30 levels were significantly higher in the A\u2010DM group than in the MA\u2010DM group (3.55\u2009\u00b1\u20094.54 <jats:italic>vs<\/jats:italic> 2.53\u2009\u00b1\u20093.83; <jats:italic>P<\/jats:italic> = 0.014, and 39.19\u2009\u00b1\u200932.19 <jats:italic>vs<\/jats:italic> 32.71\u2009\u00b1\u200928.81; <jats:italic>P<\/jats:italic> = 0.032, 675.05\u2009\u00b1\u2009475.60 <jats:italic>vs<\/jats:italic> 584.56\u2009\u00b1\u2009450.23; <jats:italic>P<\/jats:italic> =\u20090.048, respectively). The glucose disposition index (GDI) of the A\u2010DM group was statistically higher than that of the MA\u2010DM group (0.38\u2009\u00b1\u20090.40 <jats:italic>vs<\/jats:italic> 0.30\u2009\u00b1\u20090.35; <jats:italic>P<\/jats:italic> = 0.018). Age was positively associated with \u0394I30\/\u0394G30 (<jats:italic>r<\/jats:italic> = 0.117; <jats:italic>P<\/jats:italic> = 0.017) and GDI (<jats:italic>r<\/jats:italic> = 0.147; <jats:italic>P<\/jats:italic> = 0.003), but had no correlation with InsAUC30, InsAUC120 or GluAUC30\u2009\u00d7\u2009InsAUC30. After multiple adjustments for confounders, including sex, body mass index, glycated hemoglobin, triglyceride, total cholesterol and high\u2010density lipoprotein cholesterol, age was positively associated with \u0394I30\/\u0394G30, InsAUC30, InsAUC120, GluAUC30\u2009\u00d7\u2009InsAUC30 and GDI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Aged patients have relatively higher early\u2010phase insulin secretion and GDI than middle\u2010aged patients in newly diagnosed T2DM. <jats:bold>Geriatr Gerontol Int 2020; \u2022\u2022: \u2022\u2022\u2013\u2022\u2022<\/jats:bold>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ggi.13861","type":"journal-article","created":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T23:03:54Z","timestamp":1578697434000},"page":"206-211","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Differences in early\u2010phase insulin secretion and glucose disposition index between aged and middle\u2010aged patients with newly diagnosed type\u20092 diabetes"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8955-4418","authenticated-orcid":false,"given":"Yun","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Geriatrics Drum Tower Clinical Medical College of Nanjing Medical University  Nanjing China"},{"name":"Department of Endocrinology and Metabolism Geriatric Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fenghui","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Drum Tower Clinical Medical College of Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenxia","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Drum Tower Clinical Medical College of Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Geriatric Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Drum Tower Clinical Medical College of Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,1,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0908292"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1262-3636(05)73649-1"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI64095"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.100350"},{"key":"e_1_2_7_6_1","first-page":"3","article-title":"Amylin\/islet amyloid polypeptide: biochemistry, physiology, patho\u2010physiology","volume":"21","author":"Castillo MJ","year":"1995","journal-title":"Diabetes Metab"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0531-5565(00)00118-2"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-1058"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-013-3036-4"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4054"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/db05-1333"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/db16-0432"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.2337\/db13-1855"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.8.1888"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2014.04.004"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/147323001003800342"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.2337\/db08-1607"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2013.1164"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-1478"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280883"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-1519"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.12392"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012578"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-2813"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.38.12.1549"}],"container-title":["Geriatrics &amp; 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