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A recent report described the concept of rehabilitation pharmacotherapy. The concept envisages helping frail older people and people with disabilities to achieve the highest possible body function, activity level and quality of life. There are two key tenets of rehabilitation pharmacotherapy: \u201cpharmacotherapy in consideration of rehabilitation\u201d and \u201crehabilitation in consideration of pharmacotherapy.\u201d \u201cPharmacotherapy in consideration of rehabilitation\u201d includes use of drugs to treat impairment, activity limitation and participation restriction based on the International Classification of Functioning, Disability, and Health. \u201cRehabilitation in consideration of pharmacotherapy\u201d refers to tailoring of rehabilitation considering the content of pharmacotherapy. With respect to drugs and motor dysfunction, anticholinergic drugs are associated with dysphagia and fractures. Increased use of potentially inappropriate medications may adversely affect the nutritional status. With respect to activities of daily living, polypharmacy and use of potentially inappropriate medications negatively affect the improvement in motor function during rehabilitation. Potent anticholinergic drugs are more likely to impede the improvement in cognitive function. In this review, we address the concept of rehabilitation pharmacotherapy and discuss its importance from the perspective of polypharmacy, the effect of drugs on disability and disease, nutritional status and activities of daily living. <jats:bold>Geriatr Gerontol Int 2020; 20: \u2013<\/jats:bold>.<\/jats:p>","DOI":"10.1111\/ggi.13975","type":"journal-article","created":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T09:35:48Z","timestamp":1595324148000},"page":"655-663","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Rehabilitation pharmacotherapy: A scoping review"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5094-2122","authenticated-orcid":false,"given":"Eiji","family":"Kose","sequence":"first","affiliation":[{"name":"Department of Pharmacy Teikyo University School of Medicine University Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0364-0818","authenticated-orcid":false,"given":"Hidetaka","family":"Wakabayashi","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine Tokyo Women's Medical University Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgf2.163"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/7957825"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0594.2011.00783.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0594.2012.00868.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39503.424653.80"},{"key":"e_1_2_9_7_1","first-page":"e1","article-title":"Clinical and economic outcomes associated with potentially inappropriate prescribing in the elderly","volume":"16","author":"Stockl KM","year":"2010","journal-title":"Am J Manag Care"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/nur.20232"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-014-0162-x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ggi.13467"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jand.2018.02.012"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgf2.116"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2012.02.018"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-019-1250-6"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.13153"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/00207454.2010.505352"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0b013e31820172bf"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.162.20.2269"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-017-0621-2"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0594.2006.00355.x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/ggi.12591"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.2165\/11632610-000000000-00000"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61091-5"},{"key":"e_1_2_9_24_1","volume-title":"Polypharmacy and Medicines Optimisation. 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