{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T04:04:28Z","timestamp":1778558668620,"version":"3.51.4"},"reference-count":24,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T00:00:00Z","timestamp":1601251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Investigating the incidence rate of early\u2010onset dementia is challenging. We explored the incidence rate of early\u2010onset dementia in Japan using annual performance reports from the Medical Centers for Dementia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Medical Centers for Dementia are specialized health services for dementia established as part of Japan's national health program. There are 440 such centers nationwide as of 2018. Using the annual performance reports of these centers, we calculated the number of newly diagnosed cases of early\u2010onset dementia or late\u2010onset dementia from April 1, 2018 to March 31, 2019, and the composition ratio by diagnosis according to the <jats:italic>Diagnostic and Statistical Manual of Mental Disorders<\/jats:italic>, Fifth Edition. The annual incidence rate of early\u2010onset dementia was estimated using the number of cases as the numerator and the national population aged 18\u201364\u2009years as the denominator.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 1733 of cases were diagnosed with early\u2010onset dementia, of which 52.1% were diagnosed as major neurocognitive disorder due to Alzheimer's disease, 8.9% major frontotemporal neurocognitive disorder, 8.8% major vascular neurocognitive disorder, 7.1% substance\/medication\u2010induced major neurocognitive disorder, 6.5% major neurocognitive disorder with Lewy bodies and 3.9% major neurocognitive disorder due to another medical condition. The annual incidence rate of early\u2010onset dementia was estimated to be 2.47\/100\u2009000 person\u2010years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study provides the first nationwide estimate of the incidence rate of early\u2010onset dementia in Japan and suggests that Medical Centers for Dementia are important resources for the epidemiological monitoring of early\u2010onset dementia nationwide. <jats:bold>Geriatr Gerontol Int 2020; 20: 1050\u20131055.<\/jats:bold>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ggi.14043","type":"journal-article","created":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T01:33:15Z","timestamp":1601343195000},"page":"1050-1055","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Incidence and distribution of subtypes of early\u2010onset dementia in Japan: A nationwide analysis based on annual performance reports of the Medical Centers for Dementia"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6055-211X","authenticated-orcid":false,"given":"Ayako","family":"Edahiro","sequence":"first","affiliation":[{"name":"Research Team for Promoting Independence and Mental Health, Tokyo Metropolitan Institute of Gerontology  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumiko","family":"Miyamae","sequence":"additional","affiliation":[{"name":"Research Team for Promoting Independence and Mental Health, Tokyo Metropolitan Institute of Gerontology  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsutomu","family":"Taga","sequence":"additional","affiliation":[{"name":"Research Team for Promoting Independence and Mental Health, Tokyo Metropolitan Institute of Gerontology  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mika","family":"Sugiyama","sequence":"additional","affiliation":[{"name":"Research Team for 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