{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:38:39Z","timestamp":1777678719903,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T00:00:00Z","timestamp":1616976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002560","name":"Soonchunhyang University","doi-asserted-by":"publisher","award":["SCH\u201020200042"],"award-info":[{"award-number":["SCH\u201020200042"]}],"id":[{"id":"10.13039\/501100002560","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Clinical implications for motor phenotypes of Parkinson's disease (PD) remain to be further elucidated, particularly at the early stages of the disease. We aimed to compare the non\u2010motor and fall\u2010related features between tremor\u2010dominant (TD) and postural instability\u2010gait difficulty (PIGD) subtypes in patients with early PD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PD was categorized into TD, intermediate and PIGD types, according to the literature. Not only motor symptoms, but also non\u2010motor symptoms for global cognition, depression, anxiety, fatigue and dysautonomia, were measured in detail. In addition, fall\u2010related features, including a previous history of falls, fear of fall measurement and gait freezing were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In patients with early PD (disease duration no more than 5\u2009years), 35 patients with TD\u2010type PD and 31 patients with PIGD\u2010type PD were finally evaluated for the study. Compared with the TD group, the PIGD group showed higher fatigue, gastrointestinal dysfunction and fall\u2010related parameter scores. Moreover, the PIGD scores were significantly correlated with all of those symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings suggest that PIGD is significantly linked to fatigue, gastrointestinal dysfunction and fall\u2010related features during the early stages of PD. <jats:bold>Geriatr Gerontol Int 2021; 21: 416\u2013420<\/jats:bold>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ggi.14156","type":"journal-article","created":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T11:14:05Z","timestamp":1617016445000},"page":"416-420","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Impact of motor subtype on non\u2010motor symptoms and fall\u2010related features in patients with early <scp>Parkinson's<\/scp> disease"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5443-0952","authenticated-orcid":false,"given":"Kyum\u2010Yil","family":"Kwon","sequence":"first","affiliation":[{"name":"Department of Neurology Soonchunhyang University Seoul Hospital, Soonchunhyang University School of Medicine  Seoul Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Ji","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology Soonchunhyang University Seoul Hospital, Soonchunhyang University School of Medicine  Seoul Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mina","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology Soonchunhyang University Seoul Hospital, Soonchunhyang University School of Medicine  Seoul Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyunjin","family":"Ju","sequence":"additional","affiliation":[{"name":"Department of Neurology Soonchunhyang University Seoul Hospital, Soonchunhyang University School of Medicine  Seoul Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kayeong","family":"Im","sequence":"additional","affiliation":[{"name":"Department of Neurology Soonchunhyang University Seoul Hospital, Soonchunhyang University School of Medicine  Seoul Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2015.09.027"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.40.10.1529"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20513"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1017\/cjn.2015.328"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2009.221"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181ae7af1"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ane.12461"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002768"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26510"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2018.04.021"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.56.1.33"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-017-1717-8"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.111.095224"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0891988708316855"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.1664"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2018.33.e128"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2004.07.007"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.14802\/jmd.16057"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2017.04.011"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21598"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21596"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-018-3502-3"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2020.01.009"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25213"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-181375"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-014-7513-6"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2012.03821.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph16122216"}],"container-title":["Geriatrics &amp; 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