{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T08:50:46Z","timestamp":1780044646106,"version":"3.53.1"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T00:00:00Z","timestamp":1626307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Polypharmacy is known to be a risk factor for falls or bone fracture (F\/F) in elderly patients. However, this relationship is not fully described in patients with non\u2010valvular atrial fibrillation (NVAF), for which F\/F may lead to serious clinical outcomes, including major bleeding.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed 509 elderly (aged \u226575\u2009years) patients with NVAF who had recently visited a hospital specializing in cardiology, of which 272 patients had paroxysmal atrial fibrillation (PAF) and 237 had persistent\/permanent atrial fibrillation (PeAF). Patients were divided into four groups according to the number of medications: \u22643, 4\u20136, 7\u20139, and\u2009\u226510. The relationship between the number of medications and incidence rate of F\/F in AF patients was analyzed. In addition, this relationship was analyzed in patients with each AF type.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cumulative incidence of F\/F at 3\u2009years in the respective categories was 3.7%, 5.4%, 4.3% and 5.7% for PAF, and 5.2%, 7.5%, 7.8% and 25.0% for PeAF (log\u2010rank test, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.930 and 0.003, respectively). In a multivariable model, patients with \u226510 medications showed a significantly higher risk for F\/F compared with those with \u22643 medications as reference only in PeAF (adjusted hazard ratio 4.82, 95%CI 1.42\u201316.33), without significant interaction (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.081).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Elderly NVAF patients using \u226510 medications showed a higher risk for F\/F. In subgroup analysis, this association was observed only in patients with PeAF, although there was no significant interaction between number of medications and AF type. <jats:bold>Geriatr Gerontol Int 2021; 21: 802\u2013809<\/jats:bold>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ggi.14242","type":"journal-article","created":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T05:20:20Z","timestamp":1626412820000},"page":"802-809","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Relationship between number of medications and incidence of falls or bone fracture in elderly patients with non\u2010valvular atrial fibrillation: Shinken database analysis"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3859-7087","authenticated-orcid":false,"given":"Tomoki","family":"Fujisawa","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine The Cardiovascular Institute  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