{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T23:20:14Z","timestamp":1756682414582,"version":"3.40.5"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T00:00:00Z","timestamp":1642636800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Despite the increasing attention that has been paid to amyloidosis in recent years, there have been few reports on amyloidosis mortality and its trends worldwide. This study aimed to evaluate the trends in crude and age\u2010adjusted amyloidosis\u2010associated mortality rates in Japan from 1998 to 2019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used national Vital Statistics data among older adults aged over 50 years. The data were analyzed using the joinpoint regression program to estimate the long\u2010term trends and average annual percentage changes (AAPCs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 9158 amyloidosis\u2010associated deaths were recorded from 1998 to 2019, of which 56.1% were in men. The crude mortality rate per 1\u00a0000\u2009000 older adults aged over 80\u2009years increased from 9.65 to 54.3 among men and from 7.02 to 22.1 among women during the study period. Overall, the AAPCs of age\u2010adjusted amyloidosis\u2010associated mortality rates increased significantly over the study period (1.8%, 95% confidence interval [CI], 1.0\u20132.7%). While the annual percentage change (APC) of age\u2010adjusted mortality rates in women showed no significant change over the study period, the APC in men markedly increased in the 2013\u20132019 period (8.2%, 95% CI: 6.0\u201310.4%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study revealed an increasing trend in mortality associated with amyloidosis, and in particular a marked increase in mortality among men over the past 6\u2009years. Considering its high mortality rate and susceptibility to the effects of an increasing population of older adults, amyloidosis deserves more attention from healthcare providers to improve the understanding of diagnosis, clinical treatment, and healthcare planning. <jats:bold>Geriatr Gerontol Int 2022; 22: 246\u2013250<\/jats:bold>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ggi.14348","type":"journal-article","created":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T23:43:39Z","timestamp":1642722219000},"page":"246-250","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Trends in the amyloidosis mortality rate in <scp>J<\/scp>apan: A nationwide observational study from 1998 to 2019"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3801-1472","authenticated-orcid":false,"given":"Ko","family":"Harada","sequence":"first","affiliation":[{"name":"Department of Medicine Icahn School of Medicine at Mount Sinai, Mount Sinai Beth Israel  New York New York USA"},{"name":"Department of General Medicine Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideharu","family":"Hagiya","sequence":"additional","affiliation":[{"name":"Department of General Medicine Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiro","family":"Koyama","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Biomedicine Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumio","family":"Otsuka","sequence":"additional","affiliation":[{"name":"Department of General Medicine Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,1,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.13169"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2017.10.003"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.18-2-s30"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/91.2.141"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.018852"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.06.033"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv338"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2017.65"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-11-0135"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.01.016"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320340422"},{"key":"e_1_2_9_13_1","unstructured":"Ministry of Health Labour and Welfare Japan.Vital statistics of Japan. 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