{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T23:57:55Z","timestamp":1785542275369,"version":"3.56.0"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T00:00:00Z","timestamp":1644451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["17K17553"],"award-info":[{"award-number":["17K17553"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["16K12336"],"award-info":[{"award-number":["16K12336"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["15K08910"],"award-info":[{"award-number":["15K08910"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["2510211"],"award-info":[{"award-number":["2510211"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to clarify the association between dietary protein intake and decline in the estimated glomerular filtration rate (eGFR) among Japanese older adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used the data of the Septuagenarians, Octogenarians and Nonagenarians Investigation with Centenarians (SONIC) study, an ongoing narrow\u2010age range cohort study: 69\u201371\u2009years, 79\u201381\u2009years and 89\u201391\u2009years. The outcome variable, change in eGFR, was estimated from serum creatinine measured at the baseline and 3\u2010year follow up, and the exposure variable, protein intake, was calculated using the brief\u2010type self\u2010administered diet history questionnaire at the baseline. Associations between eGFR change and protein intake were determined by multiple linear regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean eGFR change per year was \u22121.89\u2009mL\/min\/1.73\u2009m<jats:sup>2<\/jats:sup>. The mean protein intake was 1.50\u2009g\/kg\/day. The results of this study showed that there was no significant association between protein or animal protein intake and change in eGFR per year in the entire population of participants, including the very elderly, but there was a significant positive association in those whose renal function fell into chronic kidney disease stage\u2009G3 or G4.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Protein intake among community\u2010dwelling older adults was not associated with lower eGFR, and for older chronic kidney disease patients, protein and animal protein intakes were more beneficial in maintaining eGFR. The results provide evidence that protein intake should not be restricted for older patients with chronic kidney disease, including the very elderly. <jats:bold>Geriatr Gerontol Int 2022; 22: 286\u2013291<\/jats:bold>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ggi.14355","type":"journal-article","created":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T09:44:14Z","timestamp":1644486254000},"page":"286-291","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Association between protein intake and changes in renal function among Japanese community\u2010dwelling older people: The SONIC study"],"prefix":"10.1111","volume":"22","author":[{"given":"Toshiaki","family":"Sekiguchi","sequence":"first","affiliation":[{"name":"Department of Health Sciences Osaka University Graduate School of Medicine  Osaka Japan"},{"name":"Faculty of Health Science Morinomiya University of Medical Sciences  Osaka 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