{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T20:16:17Z","timestamp":1776284177692,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T00:00:00Z","timestamp":1662336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To describe pulmonary nodules detected by annual low\u2010dose computed tomography (LDCT) in the elderly during a 10\u2010year follow\u2010up, and to provide a basis for clinical decision\u2010making in the elderly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this retrospective study, patients who completed at least a 3\u2010year follow\u2010up visit with annual LDCT imaging data were eligible for inclusion. The evolution of pulmonary nodules was evaluated, including malignant, suspicious malignant, benign and undetermined nodules. Additionally, the nature and outcome of new nodules during the follow\u2010up were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For the 365 subjects included, 899 positive pulmonary nodules were detected in 286 patients. Among these there were 788 solid nodules, 20 part\u2010solid nodules and 91 nonsolid nodules. The detection rate of positive nodules and of lung cancer was 78.4% and 5.5%, respectively. 99.7% (786\/788) of solid nodules were benign, and 75% (15\/20) of part\u2010solid nodules and 28.6% (26\/91) of nonsolid nodules were malignant or suspected malignant. 124 new positive nodules appeared during the annual follow\u2010up, but 58.9% of them subsequently disappeared. Significant higher detection rates of 10\u201320\u2010mm nodules (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0485) and suspicious malignant nodules (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.017) were observed in subjects over 75\u2009years old as compared with those under 75\u2009years old.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Solid nodules accounted for the highest proportion of lung nodules screened at baseline, and most of them were benign. The malignant probability of part\u2010solid nodules was the highest. Most newly appeared nodules disappeared during subsequent follow\u2010up. The proportions of suspicious malignant nodules and 10\u201320\u2010mm nodules in subjects over 75\u2009years old were higher than in those under 75\u2009years old. <jats:bold>Geriatr Gerontol Int 2022; 22: 865\u2013869<\/jats:bold>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ggi.14479","type":"journal-article","created":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T05:40:11Z","timestamp":1662442811000},"page":"865-869","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Analysis of pulmonary nodules detected by annual low\u2010dose computed tomography in the elderly during a 10\u2010year follow\u2010up"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0155-9642","authenticated-orcid":false,"given":"Zhonghui","family":"Liu","sequence":"first","affiliation":[{"name":"The Geriatrics Department Peking University First Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinmin","family":"Liu","sequence":"additional","affiliation":[{"name":"The Geriatrics Department Peking University First Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianfang","family":"Ni","sequence":"additional","affiliation":[{"name":"The Geriatrics Department Peking University First Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,9,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21338"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-40389-2_3"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1102873"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa060476"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2020.04.035"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.1117"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2018.0020"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2021.06.063"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0906085"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2008.07.003"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-020-07750-z"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2018.12.002"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-015-3620-8"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-020-00432-6"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30069-9"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2018.05.006"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.09090547"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-02582-8"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2021.4932"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.12829"}],"container-title":["Geriatrics &amp; 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