{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T17:04:09Z","timestamp":1788627849361,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Sexually transmitted infections remain a neglected area of research in geriatrics. However, in the global aging societies, sexual health among the middle\u2010aged and older adults is an emerging public concern. High\u2010income countries are facing a resurgence of syphilis cases among young generations, but little is known about its prevalence in older populations. We aimed to investigate the national trend of syphilis cases in Japan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This nationwide observational study used the publicly\u2010available database (2009\u20132019) to calculate crude and age\u2010adjusted incidence rates of syphilis per 100\u2009000 population by age, sex and clinical stage. We collected data from patients aged \u226550\u2009years and performed joinpoint regression analysis to estimate long\u2010term trends and average annual percentage changes (AAPCs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The total number of patients with syphilis increased about 8\u2010fold from 165 in 2009 to 1280 in 2019. AAPCs of crude incidence rates significantly increased in every age category; 33.2% in 50\u201359\u2009years, 23.8% in 60\u201369\u2009years and 20.9% in \u226570\u2009years. Age\u2010adjusted incidence rates have surged at AAPCs of 28.7% in men and 23.1% in women, reaching 4.09 in men and 0.71 in women in 2019. By clinical stage, marked increases were observed in primary (AAPCs, 42.3% in men and 41.6% in women) and secondary syphilis (AAPCs, 24.9% in men and 24.2% in women).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>An up\u2010toward trend of syphilis among people aged \u226550\u2009years was observed. The importance of sexual health among older people should be highlighted in this aging Japanese society. <jats:bold>Geriatr Gerontol Int 2022; 22: 1019\u20131024<\/jats:bold>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ggi.14500","type":"journal-article","created":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T05:50:52Z","timestamp":1667368252000},"page":"1019-1024","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Trends in the incidence of syphilis in the middle\u2010aged and older adults in Japan: A nationwide observational study, 2009\u20132019"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7924-9199","authenticated-orcid":false,"given":"Misa","family":"Takahashi","sequence":"first","affiliation":[{"name":"Department of General Medicine Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5086-1891","authenticated-orcid":false,"given":"Hideharu","family":"Hagiya","sequence":"additional","affiliation":[{"name":"Department of General Medicine Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiro","family":"Koyama","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Biomedicine Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumio","family":"Otsuka","sequence":"additional","affiliation":[{"name":"Department of General Medicine Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"285","article-title":"Raising health care provider awareness of sexually transmitted disease in patients over age 50","volume":"20","author":"Jeffers LA","year":"2011","journal-title":"Medsurg Nurs"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00090-07"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1903"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0143304"},{"key":"e_1_2_9_6_1","unstructured":"World Health OrganizationReport on Global Sexually Transmitted Infection Surveillance. 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