{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:29:15Z","timestamp":1780446555875,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T00:00:00Z","timestamp":1671148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["Research and Development Grant for Dementia \/ 20dk"],"award-info":[{"award-number":["Research and Development Grant for Dementia \/ 20dk"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Although sarcopenia is common in patients with Alzheimer's disease (<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>), the neural substrates involved remain unclear. We investigated the relationship between sarcopenia, as well as its definition components, and regional cerebral blood flow (<jats:styled-content style=\"fixed-case\">rCBF<\/jats:styled-content>) in older adults with progression of normal cognition to <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:sup><jats:italic>99m<\/jats:italic><\/jats:sup>Tc\u2010ethyl\u2010cysteinate\u2010dimer single\u2010photon emission computed tomography was carried out in 95 older adults with progression of normal cognition to AD (40 men and 55 women, mean\u2009\u00b1\u2009SD age 80.9\u2009\u00b1\u20096.8\u2009years). The associations of rCBF determined by 3\u2010D stereotactic region of interest template software, with sarcopenia and its definition components, slower gait speed, weaker grip strength, and decline in appendicular skeletal muscle mass index (ASMI) were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Logistic regression analysis adjusted by age, sex, mini\u2010mental state examination score and education showed that sarcopenia as well as ASMI less than the cut\u2010off (men 7.0\u2009kg\/m<jats:sup>2<\/jats:sup>, women 5.7\u00a0kg\/m<jats:sup>2<\/jats:sup>) were associated with significantly reduced rCBF in the key hub of the central autonomic network, including the insula, anterior cingulate cortex, subcallosal area, rectal gyrus, hypothalamus, amygdala and caudate head. Sarcopenia and ASMI decline were associated with hypoperfusion in the aforementioned cortical hubs of the central autonomic network in men, but with hypoperfusion of the hypothalamus in women. Linear regression analysis showed significant correlations of ASMI\/cut\u2010off with rCBF in the bilateral medial frontal cortex, as well as rCBF in the aforementioned key hubs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Hypoperfusion in key hubs of central autonomic network is implicated in the emergence of sarcopenia, probably through ASMI decline in vulnerable older adults. <jats:bold>Geriatr Gerontol Int 2023; 23: 16\u201324<\/jats:bold>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ggi.14515","type":"journal-article","created":{"date-parts":[[2022,12,17]],"date-time":"2022-12-17T04:29:26Z","timestamp":1671251366000},"page":"16-24","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Sarcopenia and decline in appendicular skeletal muscle mass are associated with hypoperfusion in key hubs of central autonomic network on <scp>3DSRT<\/scp> in older adults with progression of normal 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