{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T01:21:10Z","timestamp":1772932870493,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,1,22]],"date-time":"2023-01-22T00:00:00Z","timestamp":1674345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Alzheimer's dementia (AD) is a slowly progressing neurodegenerative disease, characterized by beta\u2010amyloid deposition and neurofibrillary tangles. Peripheral atherosclerosis may deteriorate these processes via endothelial cell dysfunction and microvascular impairment. Cilostazol \u2013 a phosphodiesterase 3 inhibitor \u2013 is a standard treatment for peripheral arterial occlusive disease and a potential treatment for preserving cognitive function in AD patients. We aimed to determine whether cilostazol is beneficial in AD patients with peripheral arterial occlusive disease by evaluating Cognitive Abilities Screening Instrument (CASI) domains.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective case\u2013control study of 62 AD patients in Taiwan. Thirty\u2010one patients had peripheral arterial occlusive disease and were receiving cilostazol plus acetylcholinesterase inhibitors (AchEIs) or <jats:italic>N<\/jats:italic>\u2010methyl <jats:sc>d<\/jats:sc>\u2010aspartate antagonists, whereas 31 others were receiving AchEIs. Therapeutic responses were measured using neuropsychological assessments. The CASI was administered at baseline and 12\u00a0months later; different domains were analyzed between the groups using univariate and multivariate analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Age, sex, education duration, ApoE \u03b54 gene status, and initial Mini\u2010Mental State Examination scores were not different between the two groups. Except for fluency, no CASI domains showed a statistical difference between the groups. A significant difference was observed in category fluency (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.010). In the logistic regression analysis, after adjusting for covariate effects, category fluency still showed a significant difference between the groups (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.013).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In AD patients with peripheral arterial occlusive disease who have received Food and Drug Administration\u2010approved pharmacotherapy, cilostazol, as an antiplatelet, may help to preserve general cognitive function, with significant preservation in category fluency. <jats:bold>Geriatr Gerontol Int 2023; 23: 194\u2013199<\/jats:bold>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ggi.14542","type":"journal-article","created":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T01:18:50Z","timestamp":1674436730000},"page":"194-199","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Cognitive effects of cilostazol in <scp>Alzheimer's<\/scp> dementia 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Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Department of Neurology, Kaohsiung Municipal Ta\u2010Tung Hospital Kaohsiung Medical University Hospital  Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuan\u2010Ying","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology Kaohsiung Medical University Hospital, Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Neuroscience Research Center Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Department of Neurology, Kaohsiung Municipal Ta\u2010Tung Hospital Kaohsiung Medical University Hospital  Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1918-9021","authenticated-orcid":false,"given":"Yuan\u2010Han","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology Kaohsiung Medical University Hospital, Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Neuroscience Research Center Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Department of Neurology, Kaohsiung Municipal Ta\u2010Tung Hospital Kaohsiung Medical University Hospital  Kaohsiung Taiwan"},{"name":"School of Post\u2010Baccalaureate Medicine, College of Medicine Kaohsiung Medical University  Kaohsiung 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