{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T08:11:22Z","timestamp":1768032682143,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T00:00:00Z","timestamp":1678665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["Practical Research Project for Renal Disease"],"award-info":[{"award-number":["Practical Research Project for Renal Disease"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["a Grant\u2010in\u2010Aid for Research on Advanced Chronic Ki"],"award-info":[{"award-number":["a Grant\u2010in\u2010Aid for Research on Advanced Chronic Ki"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016342","name":"Ministry of Health Mexico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016342","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Height loss that occurs with aging is a common phenomenon associated with musculoskeletal abnormalities, such as osteoporosis and sarcopenia. Notably, such height loss is also associated with poor outcomes, including cardiovascular disease and mortality. In this study, we investigated the relationship between height loss and kidney outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This longitudinal study includes data from the Japan Specific Health Checkups Study from 2008 to 2014. Height loss was estimated using the first three visits (visits 1\u20133), and kidney outcomes were evaluated using data from the following visits (visit 3 to the last visit). The annual height change for each participant was estimated using mixed\u2010effects model, and participants were divided into five groups according to the quintile of the rate. The association between height change and the incidence of 1.5\u2010fold increase in serum creatinine level from baseline was analyzed using Cox regression analysis. The decline rates of estimated glomerular filtration rate among the groups were compared using a mixed\u2010effects model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 187\u2009682 participants were included in the analyses. The median rate of height change was \u22120.11\u2009cm\/year. The adjusted hazard ratio (95% confidence interval) for 1.5\u2010fold increase in serum creatinine level in participants with the steepest category of height decline (Q1; Quintile 1) was 1.45 (1.26\u20131.67) compared with the reference (Q4; Quintile 4). The decline of the estimated glomerular filtration rate in Q1 (\u22121.25\u2009mL\/min\/1.73\u2009m<jats:sup>2<\/jats:sup>\/year) was significantly higher than that of the reference: Q4 (\u22120.92\u2009mL\/min\/1.73\u2009m<jats:sup>2<\/jats:sup>\/year) (<jats:italic>P<\/jats:italic> for interaction &lt;0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Height loss is associated with a rapid decline in kidney function. <jats:bold>Geriatr Gerontol Int 2023; 23: 282\u2013288<\/jats:bold>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ggi.14569","type":"journal-article","created":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T11:43:58Z","timestamp":1678707838000},"page":"282-288","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Height loss is associated with decreased kidney function: The Japan Specific Health Checkups (<scp>J\u2010SHC<\/scp>) 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