{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T13:11:04Z","timestamp":1788959464150,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T00:00:00Z","timestamp":1684713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016342","name":"Ministry of Health Mexico","doi-asserted-by":"publisher","award":["21AA2007"],"award-info":[{"award-number":["21AA2007"]}],"id":[{"id":"10.13039\/100016342","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016342","name":"Ministry of Health Mexico","doi-asserted-by":"publisher","award":["22AA2003"],"award-info":[{"award-number":["22AA2003"]}],"id":[{"id":"10.13039\/100016342","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Hypnotics might increase the risk of falls and fractures in older patients with neurocognitive disorders. Orexin receptor antagonists have recently been approved, but the relationship between the new drugs and fractures remains unclarified. This study aimed to evaluate the association between the type of hypnotic and in\u2010hospital fractures in older patients with neurocognitive disorders using a nationwide inpatient database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using the Japanese Diagnosis Procedure Combination database, we collected information on inpatients aged \u226565\u2009years with neurocognitive disorders between April 2014 and March 2021. We examined trends in the prescription patterns of benzodiazepine drugs, Z\u2010drugs, orexin receptor antagonists and melatonin receptor agonists. We also carried out a 1:4 matched case\u2013control analysis of in\u2010hospital fractures. The odds ratio of each hypnotic drug was estimated using a generalized estimating equation with adjustment for walking ability, comorbidities, osteoporosis, dialysis, selective serotonin reuptake inhibitor use and anti\u2010dementia drug use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prescription of benzodiazepine hypnotics decreased and that of orexin receptor antagonists increased. This case\u2013control analysis included 6832 patients with fractures and 23\u2009463 controls. Ultrashort\u2010acting benzodiazepines, short\u2010acting benzodiazepines and Z\u2010drugs were associated with an increased risk of bone fracture (odds ratio [95% confidence interval] 1.38 [1.08\u20131.77], 1.38 [1.27\u20131.50], 1.49 [1.37\u20131.61], respectively). Orexin receptor antagonists were not associated with an increased risk of bone fracture (1.07 [0.95\u20131.19]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In contrast to other types of hypnotics, orexin receptor antagonists were not associated with in\u2010hospital fractures in older patients with neurocognitive disorders. <jats:bold>Geriatr Gerontol Int 2023; 23: 500\u2013505<\/jats:bold>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ggi.14600","type":"journal-article","created":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T06:34:55Z","timestamp":1684823695000},"page":"500-505","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Association between the type of hypnotic drug and in\u2010hospital fractures in older patients with neurocognitive disorders: A case\u2013control study using a nationwide database"],"prefix":"10.1111","volume":"23","author":[{"given":"Shoya","family":"Matsumoto","sequence":"first","affiliation":[{"name":"Department of Geriatric Medicine, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Tamiya","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayato","family":"Yamana","sequence":"additional","affiliation":[{"name":"Data Science Center Jichi Medical University  Shimotsuke Japan"},{"name":"Department of Clinical Epidemiology and Health Economics, School of Public Health The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Hosoi","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, Graduate School of 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