{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:41:16Z","timestamp":1792096876911,"version":"4.4.0"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T00:00:00Z","timestamp":1691539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["M06M2346"],"award-info":[{"award-number":["M06M2346"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study aimed to explore the association between multimorbidity patterns with\/without frailty and future mortality among Taiwanese middle\u2010aged and older adults through a population\u2010based cohort study design.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were collected from the Taiwan Longitudinal Study on Aging. The data were obtained from Wave 3, with the multimorbidity patterns in the years of 1996 being analyzed through latent class analysis. Frailty was defined using the modified Fried criteria. The association between each disease group with\/without frailty and mortality was examined using logistic regression, with the reference group as the Relatively healthy group without frailty. Survival analysis was performed using Cox regression, and the follow\u2010up period of mortality was from 1 January 1996 to 31 December 2012.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 4748 middle\u2010aged and older adults with an average age of 66.3\u2009years (SD: 9.07\u2009years) were included. Four disease patterns were identified in 1996, namely the Cardiometabolic (21.0%), Arthritis\u2010cataract (11.9%), Relatively healthy (61.6%), and Multimorbidity (5.5%) groups. After adjusting for all covariates, the Relatively healthy group with frailty showed the highest risk for mortality (odds ratio: 3.66, 95% confidence interval [95% CI]: 2.24\u20135.95), followed by the Cardiometabolic group with frailty (odds ratio: 3.58, 95% CI: 1.96\u20136.54), Multimorbidity group with frailty (odds ratio: 2.28, 95% CI: 1.17\u20134.44), Multimorbidity group without frailty (odds ratio: 1.44, 95% CI: 1.01\u20132.04), and the Cardiometabolic group without frailty (odds ratio: 1.24, 95% CI: 1.04\u20131.49).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Frailty plays an important role in mortality among middle\u2010aged and older adults with distinct multimorbidity patterns. Middle\u2010aged and older adults with a relatively healthy multimorbidity pattern or a cardiometabolic multimorbidity pattern with frailty encountered dismal outcomes.\n                      <jats:bold>Geriatr Gerontol Int 2023; 23: 684\u2013691<\/jats:bold>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ggi.14647","type":"journal-article","created":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T07:29:46Z","timestamp":1691566186000},"page":"684-691","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Additive effect of frailty with distinct multimorbidity patterns on mortality amongst middle\u2010aged and older adults in Taiwan: A 16\u2010year population\u2010based study"],"prefix":"10.1111","volume":"23","author":[{"given":"Wei\u2010Min","family":"Chu","sequence":"first","affiliation":[{"name":"Department of Family Medicine Taichung Veterans General Hospital  Taichung Taiwan"},{"name":"School of Medicine, National Yang Ming Chiao Tung University  Hsinchu Taiwan"},{"name":"Department of Post\u2010Baccalaureate Medicine College of Medicine, National Chung Hsing University  Taichung Taiwan"},{"name":"Geriatrics and Gerontology Research Center College of Medicine, National Chung Hsing University  Taichung Taiwan"},{"name":"School of Medicine, Chung Shan Medical University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin\u2010En","family":"Ho","sequence":"additional","affiliation":[{"name":"Institute of Medicine, Chung Shan Medical University  Taichung Taiwan"},{"name":"Department of Family Medicine Taichung Armed Forces General Hospital  Taichung Taiwan"},{"name":"School of Medicine, National Defense Medical Center  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih\u2010Jung","family":"Yeh","sequence":"additional","affiliation":[{"name":"School of Public Health, Chung\u2010Shan Medical University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James Cheng\u2010Chung","family":"Wei","sequence":"additional","affiliation":[{"name":"Institute of Medicine, Chung Shan Medical University  Taichung Taiwan"},{"name":"Department of Allergy, Immunology and Rheumatology Chung Shan Medical University Hospital  Taichung Taiwan"},{"name":"Graduate Institute of Integrated Medicine, China Medical University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9000-6849","authenticated-orcid":false,"given":"Hidenori","family":"Arai","sequence":"additional","affiliation":[{"name":"National Center for Geriatrics and Gerontology  Obu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4650-395X","authenticated-orcid":false,"given":"Meng\u2010Chih","family":"Lee","sequence":"additional","affiliation":[{"name":"Institute of 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