{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T21:19:04Z","timestamp":1793135944876,"version":"4.5.0"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T00:00:00Z","timestamp":1700092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study aimed to explore the alterations in characteristics of intestinal flora, inflammatory factors and skeletal muscle mass in elderly patients affected by sarcopenia, as well as the correlation among the three, in order to provide a reference for the early identification, intervention, and treatment of sarcopenia in elderly patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A total of 206 elderly patients (\u226560\u2009years old) admitted to the Geriatric Outpatient Department of China Resources Wugang General Hospital were included in this study as the research participants. The differences in the general data, laboratory examination and intestinal flora in patients between the two groups were statistically analyzed, and the correlation between intestinal flora composition and skeletal muscle mass index, grip and inflammatory factors was also determined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The normal group and sarcopenia group exhibited a significant difference in the composition of the intestinal flora (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05). The abundance of\n                      <jats:italic>Escherichia\u2010Shigella<\/jats:italic>\n                      between the two groups was negatively correlated with the patient's relative skeletal muscle mass index and positively correlated with the interleukin\u20106 (IL\u20106) level; moreover,\n                      <jats:italic>Lacchnospira<\/jats:italic>\n                      abundance was positively correlated with relative skeletal muscle mass index;\n                      <jats:italic>Lactobacillus<\/jats:italic>\n                      and\n                      <jats:italic>Roseburia<\/jats:italic>\n                      abundance were negatively correlated with IL\u20106; and\n                      <jats:italic>Lactobacillus<\/jats:italic>\n                      ,\n                      <jats:italic>Lachnospira<\/jats:italic>\n                      , and\n                      <jats:italic>Eubacterium<\/jats:italic>\n                      _rectale_group were positively correlated with grip, and the differences were statistically significant (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Overall, it was found that elderly patients with sarcopenia have intestinal flora disorders, and the abundance of such flora was negatively correlated with the relative skeletal muscle mass index, which was positively correlated with the IL\u20106 level.\n                      <jats:bold>Geriatr Gerontol Int 2024; 24: 140\u2013146<\/jats:bold>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ggi.14661","type":"journal-article","created":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T02:34:23Z","timestamp":1700188463000},"page":"140-146","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Changes and correlation analysis of intestinal microflora composition, inflammatory index, and skeletal muscle mass in elderly patients with sarcopenia"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1070-8251","authenticated-orcid":false,"given":"Junhao","family":"Lou","sequence":"first","affiliation":[{"name":"CR &amp; WISCO General Hospital Affiliated to Wuhan University of Science and Technology  Wuhan China"},{"name":"School of Medicine, Wuhan University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Medicine, Wuhan University of Science and Technology  Wuhan China"},{"name":"Institute of Infection, Immunology and Tumor Microenvironment, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, School of Medicine Wuhan University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiongfei","family":"Wan","sequence":"additional","affiliation":[{"name":"CR &amp; WISCO General Hospital Affiliated to Wuhan University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingping","family":"Cheng","sequence":"additional","affiliation":[{"name":"CR &amp; WISCO General Hospital Affiliated to Wuhan University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,16]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"e162","article-title":"Association between low skeletal muscle mass and subclinical coronary atherosclerosis in asymptomatic individuals evaluated by CT","volume":"77","author":"Slm A","year":"2021","journal-title":"Clin Radiol"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.01081"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2019.02.001"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2020.101185"},{"key":"e_1_2_7_6_1","first-page":"57","article-title":"Circulating Interleukin\u20106 is associated with skeletal muscle strength, quality, and functional adaptation with exercise training in mobility\u2010limited older adults","volume":"9","author":"Grosicki GJ","year":"2020","journal-title":"J Frailty Aging"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2021.111330"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2016.11.006"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2019.100980"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2018.06.011"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/fcp.12500"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2018.02.002"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11081765"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2015.05.001"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11071633"},{"key":"e_1_2_7_16_1","first-page":"41","article-title":"Characterization of the gut\u2010liver\u2010muscle axis in cirrhotic patients with sarcopenia","volume":"6","author":"Ponziani FR","year":"2021","journal-title":"Liver Int"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201084031\u20100"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2019.110722"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9121303"},{"key":"e_1_2_7_20_1","first-page":"E956","article-title":"Microbiome potentiates endurance exercise through intestinal acetate production. 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