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Several metabolites; for example, resveratrol or nicotinamide mononucleotide, are reported to mimic calorie restriction effects <jats:italic>in\u2009vivo<\/jats:italic>. Metabolomic research would be useful to evaluate metabolites as biomarkers in aging\u2010relevant events and to identify metabolic regulation of aging. We recently developed the metabolomic approach for whole blood analysis, which functions as strong tool for this purpose. We review the update findings in aging\u2010relevant metabolites detected by this method. <jats:bold>Geriatr Gerontol Int 2024; 24: 44\u201348<\/jats:bold>.<\/jats:p>","DOI":"10.1111\/ggi.14684","type":"journal-article","created":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T05:20:58Z","timestamp":1697260858000},"page":"44-48","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Metabolites in aging and aging\u2010relevant diseases: Frailty, sarcopenia and cognitive decline"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1067-2244","authenticated-orcid":false,"given":"Hiroshi","family":"Kondoh","sequence":"first","affiliation":[{"name":"Geriatric Unit, Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Kameda","sequence":"additional","affiliation":[{"name":"Geriatric Unit, Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07762"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10354"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/10.1.63"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1467506"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2007.08.011"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2010.02.006"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0047-6374(94)90104-X"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.05.015"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08221"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008758"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/biof.127"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ19-0313"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aab3389"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo9120301"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.201500031"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4MB00346B"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1603023113"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07583"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI106016"},{"key":"e_1_2_8_21_1","first-page":"E409","article-title":"Carnitine metabolism in normal\u2010weight and obese human subjects during fasting","volume":"238","author":"Hoppel CL","year":"1980","journal-title":"Am J Physiol"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108295"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-36674-9"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2014.06.005"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1227166"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/56.3.M146"},{"key":"e_1_2_8_27_1","first-page":"433","article-title":"Frailty syndrome: an overview","volume":"9","author":"Chen X","year":"2014","journal-title":"Clin Interv Aging"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)04402-X"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2013.11.025"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2014.11.011"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijge.2018.03.003"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.01903"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo9050083"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12716-2"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001364"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1920795117"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.203498"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0594.2010.00585.x"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1991.tb01616.x"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2010.113"}],"container-title":["Geriatrics &amp; 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