{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T11:35:24Z","timestamp":1772710524035,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T00:00:00Z","timestamp":1699315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["JPMH21GB1002"],"award-info":[{"award-number":["JPMH21GB1002"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to clarify the relationship between high or low blood pressure (BP) and cognitive function in elderly outpatients with cardiometabolic diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We evaluated the association between BP and the Dementia Assessment Sheet for Community\u2010based Integrated Care System\u201021 items (DASC\u201021), Mini Mental State Examination (MMSE), and Montreal Cognitive Assessment Tool (MoCA) (<jats:italic>N<\/jats:italic>\u2009=\u2009677).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The patients' mean age was 79.2\u2009\u00b1\u20096.3\u2009years (male 35.3%), and BP was 132.1\u2009\u00b1\u200918.1\/73.5\u2009\u00b1\u200912.2\u2009mmHg. Systolic BP (SBP) was linearly related to the DASC\u201021 score (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.122, <jats:italic>P<\/jats:italic>\u2009=\u20090.004), but not to the MMSE score (<jats:italic>P<\/jats:italic>\u2009=\u20090.101) or MoCA score (<jats:italic>P<\/jats:italic>\u2009=\u20090.802). Multiple linear regression analysis showed that lower SBP was significantly related to the DASC\u201021 score, even after controlling for confounding factors (<jats:italic>B<\/jats:italic>\u2009=\u2009\u22120.411 per 10\u2009mmHg; 95% confidence interval [CI], \u22120.673 to \u22120.149; <jats:italic>P<\/jats:italic>\u2009=\u20090.002). Moreover, logistic regression analysis showed that lower SBP was associated with DASC\u201021\u2009\u2265\u200931 (odds ratio\u2009=\u20090.838 per 10\u2009mmHg, <jats:italic>P<\/jats:italic>\u2009=\u20090.048). An MMSE score\u2009\u226423 was significantly associated with higher SBP in patients without a history of hypertension but with lower SBP in those with hypertension, those on hypertensive medication, and those with dyslipidemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Higher BP was associated with a higher prevalence of probable dementia in those without a history of hypertension, even in late life. In those with hypertension and those taking antihypertensives with comorbidities of stroke or heart failure, lower BP was associated with probable dementia, which was largely dependent on reduced activities of daily living, as measured by the DASC\u201021 score. <jats:bold>Geriatr Gerontol Int 2024; 24: 110\u2013117<\/jats:bold>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ggi.14698","type":"journal-article","created":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T08:11:11Z","timestamp":1699344671000},"page":"110-117","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Relationship between blood pressure and cognitive impairment in elderly outpatients with cardiometabolic diseases"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8669-815X","authenticated-orcid":false,"given":"Joji","family":"Ishikawa","sequence":"first","affiliation":[{"name":"Department of Cardiology Tokyo Metropolitan Institute for Geriatrics and Gerontology  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayumi","family":"Toba","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tokyo Metropolitan Institute for Geriatrics and Gerontology  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiaki","family":"Tamura","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Metabolism, and Endocrinology Tokyo Metropolitan Institute for Geriatrics and Gerontology  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9088-2841","authenticated-orcid":false,"given":"Atsushi","family":"Araki","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Metabolism, and Endocrinology Tokyo Metropolitan Institute for Geriatrics and Gerontology  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazumasa","family":"Harada","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tokyo Metropolitan Institute for Geriatrics and Gerontology  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.7050"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.21442"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afy072"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2014.8164"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz071"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.121.17530"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-018-0955-4"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ggi.14601"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0594.2010.00585.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3810\/pgm.2009.03.1990"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ggi.12727"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcrp.2021.200104"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2019.01844"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2023.103323"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2017.00220"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-019-0284-9"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2015.4103"}],"container-title":["Geriatrics &amp; Gerontology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ggi.14698","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T03:18:58Z","timestamp":1712027938000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ggi.14698"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,7]]},"references-count":17,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1111\/ggi.14698"],"URL":"https:\/\/doi.org\/10.1111\/ggi.14698","archive":["Portico"],"relation":{},"ISSN":["1444-1586","1447-0594"],"issn-type":[{"value":"1444-1586","type":"print"},{"value":"1447-0594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,7]]},"assertion":[{"value":"2023-07-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}