{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T20:25:02Z","timestamp":1775766302345,"version":"3.50.1"},"reference-count":54,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T00:00:00Z","timestamp":1703030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Muscle mass and strength correlate with cognitive function; however, it remains unclear whether dynapenia (i.e., muscle weakness with preserved muscle mass) is relevant. This study aimed to explore whether dynapenia is associated with global cognitive function in community\u2010dwelling older Japanese adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross\u2010sectional study used data from the Integrated Research Initiative for Living Well with Dementia Cohort Study, which pooled data from five community\u2010based geriatric cohorts. Dynapenia was defined as muscle weakness without muscle mass loss according to the Asian Working Group for Sarcopenia criteria. Cognitive function was assessed using the Mini\u2010Mental State Examination (MMSE). An ordered logistic regression analysis was conducted with dynapenia as the exposure and with cognitive decline stages, defined as an MMSE score of 27\u201330 for normal cognition, 24\u201326 for possible cognitive decline, and\u2009&lt;24 for cognitive decline, as the outcome, stratified by sex and adjusted for age, muscle mass, education, alcohol consumption, smoking habits, living alone, and non\u2010communicable diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We analyzed data for 3338 participants (2162 female) with preserved muscle mass. Of these, 449 (13.5%) had dynapenia, and 79 (2.4%) exhibited cognitive decline. Multivariate odds ratios (95% confidence interval) for cognitive decline among those with dynapenia, compared with those without dynapenia, were 1.51 (1.02\u20132.24) for males and 2.08 (1.51\u20132.86) for females.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Muscle weakness is associated with cognitive decline, even in individuals with preserved muscle mass. Further studies are needed to better understand the association between muscle weakness and cognitive decline over time in order to develop dementia prevention strategies for those with dynapenia. <jats:bold>Geriatr Gerontol Int 2024; 24: 123\u2013129<\/jats:bold>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ggi.14749","type":"journal-article","created":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T10:04:40Z","timestamp":1703066680000},"page":"123-129","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Association between dynapenia and cognitive decline in community\u2010dwelling older Japanese adults: The <scp>IRIDE<\/scp> Cohort Study"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8728-5071","authenticated-orcid":false,"given":"Sho","family":"Hatanaka","sequence":"first","affiliation":[{"name":"Integrated Research Initiative for Living Well with Dementia Tokyo Metropolitan 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