{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T10:36:31Z","timestamp":1787654191510,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T00:00:00Z","timestamp":1702944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008734","name":"Mitsui Sumitomo Insurance Welfare Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008734","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To clarify the association between constipation, diarrhea, and long\u2010term laxative use in Japanese nursing home residents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from 306 residents with chronic constipation aged over 75\u2009years for basic characteristics, medication use, activities of daily living, and concurrent illness were collected via two consecutive 6\u2010monthly surveys conducted using the Japanese interRAI assessment tool. We used bivariate and multivariate analyses to examine the associations between chronic constipation, diarrhea, and continuous laxative use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Chronic constipation persisted in 74.5% of residents despite their continuous use of laxatives. Additionally, 14.4% experienced chronic diarrhea while on laxatives. Residents using salt laxatives had significantly lower chronic constipation than those not using salt laxatives (adjusted odds ratio [AOR] 0.52), while residents using novel laxatives had significantly higher chronic diarrhea than those not using novel laxatives (AOR 4.28).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings reveal that bowel movement\u2010related problems remain a concern and highlight the need for further research on the use of novel laxatives in nursing home residents. <jats:bold>Geriatr Gerontol Int 2024; 24: 133\u2013139<\/jats:bold>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ggi.14777","type":"journal-article","created":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T07:01:15Z","timestamp":1703055675000},"page":"133-139","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Continuous laxative use and its relationship to defecation among residents of nursing homes: A longitudinal observational study using the <scp>interRAI<\/scp>"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9136-0164","authenticated-orcid":false,"given":"Manami","family":"Takaoka","sequence":"first","affiliation":[{"name":"Department of Gerontological Home Care and Long\u2010term Care Nursing The University of Tokyo  Bunkyo\u2010ku Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5292-8893","authenticated-orcid":false,"given":"Ayumi","family":"Igarashi","sequence":"additional","affiliation":[{"name":"Department of Gerontological Home Care and Long\u2010term Care Nursing The University of Tokyo  Bunkyo\u2010ku Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayako","family":"Ninomiya","sequence":"additional","affiliation":[{"name":"Faculty of Nursing Josai International University  Togane Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoaki","family":"Ishibashi","sequence":"additional","affiliation":[{"name":"The Dia Foundation for Research on Ageing Societies  Shinjuku\u2010ku Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1704-7011","authenticated-orcid":false,"given":"Noriko","family":"Yamamoto\u2010Mitani","sequence":"additional","affiliation":[{"name":"Department of Gerontological Home Care and Long\u2010term Care Nursing The University of Tokyo  Bunkyo\u2010ku Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,19]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"119","article-title":"Prevalence and factors associated with faecal impaction in the Spanish old population","volume":"46","author":"Serrano Falc\u00f3n B","year":"2017","journal-title":"Age 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