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However, its usefulness in late\u2010stage older adults remains unclear. We aimed to determine the usefulness of CCR as an indicator of sarcopenia in community\u2010dwelling Japanese adults aged &gt;75\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Our study recruited participants aged 70, 80, and 90\u2009\u00b1\u20091\u2009years during the baseline years, and included a 3\u2010year follow\u2010up in the Septuagenarians, Octogenarians, Nonagenarians, Investigation with Centenarians study. From 2015 to 2018, 955 participants were eligible: 367 in their 70s, 304 in their 80s, and 284 in their 90s. The diagnostic components of sarcopenia, including \u201clow muscle mass, plus low muscle strength, and\/or low physical performance,\u201d were evaluated using the bioelectrical impedance analysis\u2010measured skeletal muscle mass index (SMI), handgrip strength, and short physical performance battery (SPPB) score, respectively, in accordance with the Asia Working Group for Sarcopenia 2019 criteria. Separate analyses were performed between each component and CCR, adjusting for sex, body mass index, and other blood biomarkers in each group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The relationship between CCR and sarcopenia components was significant for handgrip strength (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.21, 0.13, 0.19, and <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001, =0.0088, &lt;0.0001, for the 70s, 80s, and 90s age groups, respectively); however, it was limited for SMI (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.14; <jats:italic>P<\/jats:italic>\u2009=\u20090.0022, only for the 90s) and not significant for the SPPB score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CCR is a limited indicator of sarcopenia in late\u2010stage older adults. Although its association with muscle strength was significant, its relationship with muscle mass and physical performance was less pronounced. <jats:bold>Geriatr Gerontol Int 2024; 24: 529\u2013536<\/jats:bold>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ggi.14876","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T01:19:55Z","timestamp":1713230395000},"page":"529-536","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Usefulness of the serum creatinine\/cystatin C ratio as a blood biomarker for sarcopenia components among age groups in community\u2010dwelling older people: The SONIC study"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4585-4491","authenticated-orcid":false,"given":"Wen","family":"Fang","sequence":"first","affiliation":[{"name":"Division of Health Sciences Osaka University, Graduate School of Medicine  Osaka 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Supercentenarian Medical Research Keio University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukie","family":"Masui","sequence":"additional","affiliation":[{"name":"Research Team for Human Care Tokyo Metropolitan Institute of Gerontology  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1277-7293","authenticated-orcid":false,"given":"Tatsuro","family":"Ishizaki","sequence":"additional","affiliation":[{"name":"Research Team for Human Care Tokyo Metropolitan Institute of Gerontology  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saori","family":"Yasumoto","sequence":"additional","affiliation":[{"name":"Department of Clinical Thanatology and Geriatric Behavioral Sciences Osaka University, Graduate School of Human Sciences  Osaka 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