{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:11:56Z","timestamp":1747185116037,"version":"3.40.5"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T00:00:00Z","timestamp":1719360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Patients with dementia with Lewy bodies (DLB) are at a high risk for falls and fractures. Although cholinesterase inhibitors reportedly are effective in suppressing the progression of cognitive symptoms in DLB patients, their effects on fracture risk remain unclarified. This study aimed to evaluate the association between donepezil use and hip fracture risk in older patients with DLB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using the Japanese insurance claim database, we collected the data of patients aged \u226565\u2009years with DLB from April 2012 to March 2019. After propensity score matching, we compared the fracture rate over 3\u2009years between DLB patients receiving donepezil and those not receiving antidementia drugs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Altogether, 24\u2009022\u2009239 individuals aged \u226565\u2009years were newly registered from April 2012 to March 2016 and had verifiable information from 6\u2009months before to 3\u2009years after the registration. We identified 6634 pure\u2010DLB patients and analyzed the data of 1182 propensity score\u2010matched pairs. The characteristics, including age, sex, fracture history, osteoporosis, and bone mineral density test rate, of the two groups were well balanced by propensity score matching. The incidence rate of hip fracture was significantly lower in DLB patients receiving donepezil than in those not receiving antidementia drugs (0.60 vs. 1.44\/100 person\u2010years, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), whereas that of vertebral fractures was the same.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Donepezil administration in Japanese people aged \u226565\u2009years with DLB was significantly associated with a decreased risk of hip fracture. Donepezil may provide new benefits to DLB patients. <jats:bold>Geriatr Gerontol Int 2024; 24: 782\u2013788<\/jats:bold>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ggi.14929","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T10:21:08Z","timestamp":1719397268000},"page":"782-788","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Relationship between donepezil and fracture risk in patients with dementia with <scp>Lewy<\/scp> bodies"],"prefix":"10.1111","volume":"24","author":[{"given":"Shoya","family":"Matsumoto","sequence":"first","affiliation":[{"name":"Department of Geriatric Medicine, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsutaka","family":"Yakabe","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, Graduate School of Medicine The University of Tokyo  Tokyo 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