{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T18:57:33Z","timestamp":1769626653341,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T00:00:00Z","timestamp":1727654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Although the use of benzodiazepine receptor agonists is a risk factor for falls and fractures, whether benzodiazepine\u2010avoiding hypnotic bundles are beneficial in clinical settings remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A new hospital\u2010wide standardized hypnotic bundle for insomnia, with suvorexant as the first choice, was created for clinical purposes. This single\u2010center retrospective cohort study involved a pre\u2010post design and adult inpatients who had had falls. The primary outcome was the total fall rate in the pre\u2010post groups. Additionally, the level change in the fall\u2010rate trend for each month at standardization of the new hypnotic bundle was analyzed. The numbers of hypnotic\u2010related falls and injuries requiring treatment were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no differences in baseline characteristics between the two groups, except for patients with COVID\u201019. Overall, 31\u2009736 patients were included in this study. The total number of falls was 924 (3.42\u2030) in the pre\u2010standardization group and 837 (3.31\u2030) in the post\u2010standardization group, with no significant difference. An interrupted time\u2010series analysis of the level change in the fall rate revealed that the gap in trend at standardization was \u201311%, with no significance. Hypnotic\u2010related falls were 300 (1.11\u2030) versus 213 (0.84\u2030), and the injury incidences were 251 (0.93\u2030) versus 181 (0.71\u2030) in the pre and post groups, respectively, showing a significant reduction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The standardization of the new hypnotic bundle for insomnia did not help achieve a significant reduction in total falls. However, our findings suggest that this bundle has the potential to reduce hypnotic\u2010related falls and injuries in inpatients who have had falls. <jats:bold>Geriatr Gerontol Int 2024; 24: 1144\u20131149<\/jats:bold>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ggi.14985","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T22:49:57Z","timestamp":1727736597000},"page":"1144-1149","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of standardized hypnotic bundles on insomnia during hospitalization and reducing fall rate: A single\u2010center retrospective cohort study"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2039-7992","authenticated-orcid":false,"given":"Yuta","family":"Yoshino","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Saitama Citizens Medical Center  Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Fudaka","sequence":"additional","affiliation":[{"name":"Department of Nursing Saitama Citizens Medical Center  Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumiko","family":"Shibasaki","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Saitama Citizens Medical Center  Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miyuki","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Nursing Saitama Citizens Medical Center  Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshimasa","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Medical Safety Saitama Citizens Medical Center  Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198812293192604"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.83.5.694"},{"key":"e_1_2_9_4_1","first-page":"195","article-title":"Changes in trends of diseases requiring long\u2010term care in an aging community","volume":"68","author":"Takahashi K","year":"2021","journal-title":"Jpn J Public Health"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.2024"},{"key":"e_1_2_9_6_1","article-title":"Interventions for preventing falls in older people living in the community","volume":"9","author":"Gillespie LD","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.15767"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38623.768588.47"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2019.1196"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.12788\/jhm.2739"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmacy6020030"},{"key":"e_1_2_9_12_1","first-page":"254","article-title":"Dual orexin receptor antagonists show distinct effects on locomotor performance, ethanol interaction and sleep architecture relative to gamma\u2010aminobutyric acid\u2010A receptor modulators","volume":"24","author":"Ramirez AD","year":"2013","journal-title":"Front Neurosci"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1993.tb06708.x"},{"key":"e_1_2_9_14_1","first-page":"1","article-title":"A report of the Kellogg international work group on the prevention of falls by the elderly","volume":"34","author":"The prevention of falls in later life","year":"1987","journal-title":"Dan Med Bull"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0594.2012.00868.x"},{"key":"e_1_2_9_16_1","unstructured":"The Implementation Guide for the NQF Endorsed Nursing\u2010Sensitive Care Measure Set 2009 ver 2.0 [monograph on the Internet]. 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