{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:23:27Z","timestamp":1773012207127,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,1,5]],"date-time":"2025-01-05T00:00:00Z","timestamp":1736035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,1,5]],"date-time":"2025-01-05T00:00:00Z","timestamp":1736035200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100016399","name":"Japan Osteoporosis Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18K18447"],"award-info":[{"award-number":["18K18447"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19H05654"],"award-info":[{"award-number":["19H05654"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21K18291"],"award-info":[{"award-number":["21K18291"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21K19631"],"award-info":[{"award-number":["21K19631"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25670293"],"award-info":[{"award-number":["25670293"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["26670307"],"award-info":[{"award-number":["26670307"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["B19H03895"],"award-info":[{"award-number":["B19H03895"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["B26293139"],"award-info":[{"award-number":["B26293139"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["B26293329"],"award-info":[{"award-number":["B26293329"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["B26293331"],"award-info":[{"award-number":["B26293331"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["17dk0110028h0001"],"award-info":[{"award-number":["17dk0110028h0001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["17gk0210007h0003"],"award-info":[{"award-number":["17gk0210007h0003"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["19gk0210018h0002"],"award-info":[{"award-number":["19gk0210018h0002"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008734","name":"Mitsui Sumitomo Insurance Welfare Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008734","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017684","name":"Japan Dairy Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017684","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016626","name":"Japanese Orthopaedic Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016626","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["08033011\u201000262"],"award-info":[{"award-number":["08033011\u201000262"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["19FA0701"],"award-info":[{"award-number":["19FA0701"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["19FA1401"],"award-info":[{"award-number":["19FA1401"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["19FA1901"],"award-info":[{"award-number":["19FA1901"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["H25\u2010Choujyu\u2010007"],"award-info":[{"award-number":["H25\u2010Choujyu\u2010007"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["H25\u2010Nanchitou (Men)\u2010005"],"award-info":[{"award-number":["H25\u2010Nanchitou (Men)\u2010005"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study aims to investigate the impact of aging on brain volume among community residents in Japan, focusing on trends over time and specific brain structures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed data from the fourth survey (2015\u20132016) of the Research on Osteoarthritis\/Osteoporosis Against Disability project, encompassing 2146 community residents from Japan's mountainous and coastal regions. A total of 1755 participants (81.8% of the baseline population) underwent extensive data collection including lifestyle and health questionnaires, anthropometric measurements and brain magnetic resonance imaging. The imaging data were processed to examine correlations between total brain volume, gray matter volume (GMV), white matter volume (WMV), cerebrospinal fluid volume and participant age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Analysis showed significant sex differences in total brain volume, with GMV demonstrating a strong negative correlation with age \u2013 more pronounced than the moderate negative correlation seen in WMV. Cerebrospinal fluid volume exhibited a strong positive correlation with age. Notably, specific brain regions such as the bilateral amygdala, hippocampus, thalamus and primary motor cortex showed significant age\u2010related volume reductions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This study confirms that GMV and WMV are smaller in older individuals in the Japanese population, with more pronounced differences in GMV. The amygdala, hippocampus, thalamus and primary motor cortex were particularly affected.\n                      <jats:bold>Geriatr Gerontol Int 2025; 25: 279\u2013286<\/jats:bold>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ggi.15033","type":"journal-article","created":{"date-parts":[[2025,1,5]],"date-time":"2025-01-05T23:46:43Z","timestamp":1736120803000},"page":"279-286","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Investigation of brain volume changes associated with aging: Results from the fourth research on osteoarthritis\/osteoporosis against disability survey"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0016-5361","authenticated-orcid":false,"given":"Koji","family":"Nakajima","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, Sensory and Motor System Medicine, Graduate School of Medicine The University of Tokyo  Tokyo Japan"},{"name":"Department of Neurophysiology Juntendo University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akitoshi","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Neurophysiology Juntendo University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyasu","family":"Kodama","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Sensory and Motor System Medicine, Graduate School of Medicine The University of Tokyo  Tokyo Japan"},{"name":"Department of Neurophysiology Juntendo University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiko","family":"Shirokoshi","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Sensory and Motor System Medicine, Graduate School of Medicine The University of Tokyo  Tokyo Japan"},{"name":"Department of Neurophysiology Juntendo University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Osada","sequence":"additional","affiliation":[{"name":"Department of Neurophysiology Juntendo University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiki","family":"Konishi","sequence":"additional","affiliation":[{"name":"Department of Neurophysiology Juntendo University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiaki","family":"Horii","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Sensory and Motor System Medicine, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Oshima","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Sensory and Motor System Medicine, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiko","family":"Iidaka","sequence":"additional","affiliation":[{"name":"Department of Prevention Medicine for Locomotive Organ Disorders, 22nd Century Medical and Research Center The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeyuki","family":"Muraki","sequence":"additional","affiliation":[{"name":"Department of Prevention Medicine for Locomotive Organ Disorders, 22nd Century Medical and Research Center The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Oka","sequence":"additional","affiliation":[{"name":"Division of Musculoskeletal AI System Development, Faculty of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Kawaguchi","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Tokyo Neurological Center  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Akune","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery National Rehabilitation Center for Persons With Disabilities  Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Hashizume","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Wakayama Medical University School of Medicine  Wakayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Wakayama Medical University School of Medicine  Wakayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Munehito","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Wakayama Medical University School of Medicine  Wakayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kozo","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Towa Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Shojima","sequence":"additional","affiliation":[{"name":"Department of\u2009Neurosurgery Teikyo University Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sakae","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Sensory and Motor System Medicine, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriko","family":"Yoshimura","sequence":"additional","affiliation":[{"name":"Department of Prevention Medicine for Locomotive Organ Disorders, 22nd Century Medical and Research Center The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ggi.12450"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ggi.14201"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0594.2011.00776.x"},{"key":"e_1_2_8_5_1","volume-title":"The Care Society: a Horizon for Sustainable Recovery with Gender Equality","year":"2022"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cger.2013.07.003"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/1715163517690745"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2009.106"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-009-0080-8"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyp276"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.07.007"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-200312000-00022"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(03)00169-1"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0786"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02252964"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1996.01830070031007"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.22423"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2003.09.002"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1008"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci12111517"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3550-16.2017"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2018.00235"},{"key":"e_1_2_8_23_1","first-page":"453","article-title":"A voxel\u2010based morphometric study of age\u2010 and sex\u2010related changes in white matter volume in the normal aging brain","volume":"12","author":"Liu H","year":"2016","journal-title":"Neuropsychiatr Dis Treat"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2019.101697"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2017.0502"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.18153"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.60.12.1201"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2013.10.011"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandc.2023.105960"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhad358"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002340100688"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(95)00014-A"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.52.7.1397"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2018.00209"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-9280.2008.02258.x"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhab006"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1162\/jocn_a_00392"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-022-00630-3"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000436078.95856.56"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3732-07.2008"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.27568"},{"key":"e_1_2_8_42_1","first-page":"1524","article-title":"Reproducibility of primary motor cortex somatotopy under controlled conditions","volume":"23","author":"Alkadhi H","year":"2002","journal-title":"Am J Neuroradiol"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200211150-00015"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.01113.2002"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-001-0905-8"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-022-01324-8"}],"container-title":["Geriatrics &amp; Gerontology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ggi.15033","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ggi.15033","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ggi.15033","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:07:18Z","timestamp":1773007638000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ggi.15033"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,5]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1111\/ggi.15033"],"URL":"https:\/\/doi.org\/10.1111\/ggi.15033","archive":["Portico"],"relation":{},"ISSN":["1444-1586","1447-0594"],"issn-type":[{"value":"1444-1586","type":"print"},{"value":"1447-0594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,5]]},"assertion":[{"value":"2024-07-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}