{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T07:43:50Z","timestamp":1765439030466,"version":"3.41.0"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T00:00:00Z","timestamp":1737331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Septic older adults represent a vulnerable population with high mortality rates. Base excess (BE), an indicator of acid\u2013base status, may serve as a prognostic marker in sepsis.<\/jats:p><jats:p>This study aimed to investigate the association between BE and mortality in septic older adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis included septic older adults (age\u2009\u2265\u200965\u2009years) from the Medical Information Mart for Intensive Care (MIMIC)\u2010IV database. The primary outcome was 30\u2010day mortality. Multivariate Cox regression models and Kaplan\u2013Meier analysis were used to assess the association between BE and 30\u2010day mortality. A two\u2010segment linear regression model with smooth curve fitting was employed to examine threshold effects of BE on clinical outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study comprised 7379 participants, with a 21.8% 30\u2010day mortality rate and an 18.6% in\u2010hospital mortality rate. A nonlinear, U\u2010shaped relationship (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) was observed between BE and 30\u2010day mortality in septic older adults, indicating increased risk with higher or lower BE levels. Various BE groups showed different hazard ratios for mortality: 2.7 (2.26\u20133.22), 1.86 (1.65\u20132.09), 1.41 (1.19\u20131.67), and 1.9 (1.4\u20132.58), respectively, compared with the reference group (\u22123\u2009mEq\/L\u2009\u2264\u2009BE\u2009&lt;\u20093\u2009mEq\/L). The inflection point was calculated as 0.5\u2009mEq\/L.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings suggest a U\u2010shaped relationship between BE and mortality in septic older adults, emphasizing the importance of monitoring acid\u2013base status in sepsis management for this population. <jats:bold>Geriatr Gerontol Int 2025; 25: 380\u2013386<\/jats:bold>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ggi.15080","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T01:39:21Z","timestamp":1737423561000},"page":"380-386","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association between base excess and mortality in septic older adults"],"prefix":"10.1111","volume":"25","author":[{"given":"Qiang","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery Hekou District People's Hospital  Dongying City China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxiu","family":"Miao","sequence":"additional","affiliation":[{"name":"Department of Operating Theatre Dongying People's Hospital (Dongying Hospital of Shandong Provincial Hospital Group)  Dongying City China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fenghua","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology Hekou District Traditional Chinese Medicine Hospital  Dongying City China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianhua","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiology Hekou District People's Hospital  Dongying City China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology Dongying People's Hospital (Dongying Hospital of Shandong Provincial Hospital Group)  Dongying City China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6361-8463","authenticated-orcid":false,"given":"Na","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Hekou District People's Hospital  Dongying City China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.16194"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2017.07.010"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.20471\/acc.2022.61.s1.11"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/2048872619898781"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.12939"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.942485"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.779627"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12873-021-00465-9"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11206125"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.101.23.e215"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1711860"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001340051352"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0205309"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e15990"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2016.57.6.1361"}],"container-title":["Geriatrics &amp; Gerontology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ggi.15080","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T02:41:52Z","timestamp":1748313712000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ggi.15080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,20]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1111\/ggi.15080"],"URL":"https:\/\/doi.org\/10.1111\/ggi.15080","archive":["Portico"],"relation":{},"ISSN":["1444-1586","1447-0594"],"issn-type":[{"type":"print","value":"1444-1586"},{"type":"electronic","value":"1447-0594"}],"subject":[],"published":{"date-parts":[[2025,1,20]]},"assertion":[{"value":"2024-07-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}