{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T08:05:52Z","timestamp":1783757152050,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T00:00:00Z","timestamp":1737331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002560","name":"Soonchunhyang University","doi-asserted-by":"publisher","award":["202410004"],"award-info":[{"award-number":["202410004"]}],"id":[{"id":"10.13039\/501100002560","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Patients with Parkinson's disease (PD) present with both motor and non\u2010motor symptoms, and understanding the interplay between these symptoms is crucial for individualized patient care. This study aims to investigate the relationship between motor features and non\u2010motor symptoms in patients with de novo PD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 105 patients were analyzed, focusing on motor subtypes or subscores and their impact on cognition, depression, anxiety, fatigue, and dysautonomia. We utilized the Unified Parkinson's Disease Rating Scale\u2013part III (UPDRS\u2010III) for motor assessment, and various validated scales for non\u2010motor symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with tremor\u2010dominant (TD) patients, non\u2010TD patients showed severe scores in fatigue and dysautonomia, but no difference in other non\u2010motor symptoms, including global cognition, depression, and anxiety. Linear regression analysis revealed that the total motor score of UPDRS\u2010III was negatively related to global cognition (\u03b2\u2009=\u2009\u22120.4454, <jats:italic>P<\/jats:italic>\u2009=\u20090.0121). As a post\u2010hoc analysis, partial correlation analysis showed that rigidity and bradykinesia subscores were associated with global cognition (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.3527, <jats:italic>P<\/jats:italic>\u2009=\u20090.0004; <jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.2206, <jats:italic>P<\/jats:italic>\u2009=\u20090.0299, respectively), whereas the postural instability\/gait difficulty subscore was associated with depression, anxiety, fatigue, and dysautonomia (<jats:italic>r<\/jats:italic>\u2009=\u20090.2181, <jats:italic>P<\/jats:italic>\u2009=\u20090.0319; <jats:italic>r<\/jats:italic>\u2009=\u20090.2371, <jats:italic>P<\/jats:italic>\u2009=\u20090.0194; <jats:italic>r<\/jats:italic>\u2009=\u20090.3659, <jats:italic>P<\/jats:italic>\u2009=\u20090.0002; <jats:italic>r<\/jats:italic>\u2009=\u20090.3968, <jats:italic>P<\/jats:italic>\u2009=\u20090.0001, respectively) but not with global cognition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results suggest that motor features in the early stages of PD can serve as important indicators of non\u2010motor symptoms, potentially guiding more personalized therapeutic approaches. <jats:bold>Geriatr Gerontol Int 2025; 25: 392\u2013397<\/jats:bold>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ggi.15083","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T03:23:41Z","timestamp":1737429821000},"page":"392-397","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Impact of motor features on non\u2010motor symptoms in patients with de novo <scp>Parkinson's<\/scp> disease: Cognition, depression, anxiety, fatigue, and dysautonomia"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5443-0952","authenticated-orcid":false,"given":"Kyum\u2010Yil","family":"Kwon","sequence":"first","affiliation":[{"name":"Department of Neurology Soonchunhyang University Seoul Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung\u2010Euk","family":"Joo","sequence":"additional","affiliation":[{"name":"Department of Neurology Soonchunhyang University Seoul Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihwan","family":"You","sequence":"additional","affiliation":[{"name":"Department of Neurology Soonchunhyang University Seoul Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rae On","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology Soonchunhyang University Seoul Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27602"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/practneurol-2013-000741"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2017.62"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23462"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2023.1252596"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2018-319008"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.24041"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-41662-9"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.3.181"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.14802\/jmd.22045"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2022.0299"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.40.10.1529"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0891988708316855"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.1664"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2018.33.e128"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2004.07.007"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.14802\/jmd.16057"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.601225"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-014-7459-8"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-15630-8"}],"container-title":["Geriatrics &amp; 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