{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:34:11Z","timestamp":1792683251320,"version":"4.5.0"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T00:00:00Z","timestamp":1745193600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24K19046"],"award-info":[{"award-number":["24K19046"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Sarcopenia is recognized as an age\u2010related muscle disease, but there has been no comprehensive analysis of what is different between normal aging and sarcopenia, with an awareness of the worldwide research to date. Therefore, in this study, we used text mining of PubMed articles on sarcopenia and focused our bioinformatics analysis on the items that have been identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study compared gene\u2010level changes in sarcopenia and normal aging to identify sarcopenia\u2010specific gene changes using high\u2010throughput sequencing data. In particular, text mining analysis was used to identify pathways and mechanisms of interest in sarcopenia research, and focus more on these mechanisms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified the pathways common to sarcopenia and normal aging. Interleukin\u20107 pathways were associated with both conditions. Although changes in phagosome\u2010related pathways were suggested as sarcopenia\u2010specific, no significant changes in phagosome formation, lysosome\u2010related and mitophagy\u2010related gene groups were identified. However, genes in the nicotinamide adenine dinucleotide phosphate oxidase catalytic subunit family were shown to be possibly altered, suggesting the involvement of oxidative stress regulatory pathways.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A comprehensive bioinformatics analysis, complemented by the text mining of the extant literature, suggested that sarcopenia might not be characterized by a failure of autophagy as a whole, but rather, by a disruption of oxidative stress regulation, particularly nicotinamide adenine dinucleotide phosphate oxidase catalytic subunit\u2010related pathways at a subsequent stage of autophagy after phagosome\u2010lysosome fusion. <jats:bold>Geriatr Gerontol Int 2025; 25: 806\u2013814<\/jats:bold>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ggi.70042","type":"journal-article","created":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T10:01:26Z","timestamp":1745229686000},"page":"806-814","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Deciphering the relationship between sarcopenia and aging: A combined text mining and bioinformatics approach"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4592-4170","authenticated-orcid":false,"given":"Takahiro","family":"Kamihara","sequence":"first","affiliation":[{"name":"Department of Cardiology National Center for Geriatrics and Gerontology  Obu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5490-8653","authenticated-orcid":false,"given":"Takuya","family":"Omura","sequence":"additional","affiliation":[{"name":"Department of Metabolic Research National Center for Geriatrics and Gerontology  Obu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuya","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Cardiology National Center for Geriatrics and Gerontology  Obu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12147"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.103987"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2024.2333717"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115147"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-016-1933-3"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2021.1995151"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1253\/circrep.CR-24-0019"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/agm2.12329"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.5195\/jmla.2022.1434"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13694-1"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.244"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-22168-2"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afq034"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks1193"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky311"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq562"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1109\/tcbb.2014.2361348"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/28.1.27"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/4807853"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-09-3560"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00094.2009"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1006\/exmp.2002.2418"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.25260"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1253\/circrep.CR-22-0130"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1159\/000540095"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1159\/000537923"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/ggi.14098"}],"container-title":["Geriatrics &amp; 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