{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T22:09:07Z","timestamp":1764194947029,"version":"build-2065373602"},"reference-count":45,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T00:00:00Z","timestamp":1750723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Autonomic dysfunction and motor symptoms are prevalent in Parkinson's disease (PD). Motor symptoms influence sarcopenia; however, the association between sarcopenia and non\u2010motor symptoms, particularly autonomic dysfunction, remains unclear. This study determined the effect of autonomic dysfunction on sarcopenia in patients with PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Consecutive patients with PD (Hoehn and Yahr stages 1\u20133) without apparent dementia were screened. The Scales for Outcomes in Parkinson's Disease\u2010Autonomic Questionnaire (SCOPA\u2010AUT) was utilized to evaluate the severity of autonomic dysfunction. Sarcopenia was assessed using the 2019 Asian Diagnostic Criteria. This study examined whether the SCOPA\u2010AUT and its domains were associated with sarcopenia and used receiver operating characteristic analysis to evaluate their predictive performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 124 patients (76 [61%] men; median age, 68\u2009years) included, sarcopenia was identified in 31 (25%). Poisson regression analysis with a robust variance estimator showed that a higher SCOPA\u2010AUT score is associated with sarcopenia (prevalence ratio 1.078, 95% CI 1.034\u20131.122,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Regarding SCOPA\u2010AUT domains, higher scores for gastrointestinal functioning, urinary functioning and pupillomotor functioning were significantly associated with sarcopenia. Receiver operating characteristic analysis showed that the optimal cut\u2010off value for SCOPA\u2010AUT was 16 (area under the curve 0.730, 95% CI 0.615\u20130.844). For each SCOPA\u2010AUT domain, a cut\u2010off of 8 for gastrointestinal functioning (area under the curve 0.744, 95% CI 0.630\u20130.858) predicted sarcopenia more reliably than urinary and pupillomotor functioning.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Higher SCOPA\u2010AUT scores, particularly in the gastrointestinal function domain, might be an optimal predictive marker for sarcopenia in patients with PD.\n                      <jats:bold>Geriatr Gerontol Int 2025; 25: 1074\u20131081<\/jats:bold>\n                      .\n                    <\/jats:p>\n                  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