{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T14:23:15Z","timestamp":1788272595750,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["dk0110040"],"award-info":[{"award-number":["dk0110040"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["ek0210066"],"award-info":[{"award-number":["ek0210066"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Adrenomedullin exerts a vasodilative effect and is thought to be associated with skeletal muscle properties by regulating microcirculation. This cross\u2010sectional study aimed to clarify the possible association in older adults aged \u226565\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study population included 978 community residents (mean age 71.5\u2009years) who participated in the medical checkup. Mid\u2010thigh skeletal muscle mass and fat infiltration into the muscle was assessed using computed tomography images. Plasma levels of mid\u2010regional pro\u2010adrenomedullin, a stable fragment derived from pro\u2010adrenomedullin in a 1:1 ratio with adrenomedullin, were measured using blood drawn at the medical checkup, and quartiles were calculated for analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mid\u2010regional pro\u2010adrenomedullin did not show significant association with the mid\u2010thigh skeletal muscle cross\u2010sectional area, an index of muscle mass (Q1: 217\u2009\u00b1\u200950, Q2: 218\u2009\u00b1\u200948, Q3: 215\u2009\u00b1\u200948, Q4: 212\u2009\u00b1\u200945\u2009cm<jats:sup>2<\/jats:sup>, <jats:italic>P<\/jats:italic>\u2009=\u20090.544). Muscle subtype analysis showed that mid\u2010regional pro\u2010adrenomedullin was inversely associated with fewer fat (high intensity) muscle areas and positively associated with fat\u2010rich (low intensity) muscle areas, resulting in an inverse association with mean muscle intensity, an index of muscle quality (Q1: 50.3\u2009\u00b1\u20094.2, Q2: 49.6\u2009\u00b1\u20094.5, Q3: 49.1\u2009\u00b1\u20094.3, Q4: 47.1\u2009\u00b1\u20094.6\u2009HU, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). This association remained significant after adjustment of possible covariates, including anthropometric factors and glycemic factors (Q1: reference, Q2: \u03b2\u2009=\u2009\u22120.078, <jats:italic>P<\/jats:italic>\u2009=\u20090.018, Q3: \u03b2\u2009=\u2009\u22120.099, <jats:italic>P<\/jats:italic>\u2009=\u20090.004, Q4: \u03b2\u2009=\u2009\u22120.180, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Adrenomedullin is associated with muscle quality, but not with muscle mass. <jats:bold>Geriatr Gerontol Int 2025; 25: 1418\u20131424<\/jats:bold>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ggi.70155","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T10:05:43Z","timestamp":1756807543000},"page":"1418-1424","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association between plasma mid\u2010regional pro\u2010adrenomedullin levels and muscle properties"],"prefix":"10.1111","volume":"25","author":[{"given":"Hiroshi","family":"Akasaka","sequence":"first","affiliation":[{"name":"Department of Hygiene and Preventive Medicine, School of Medicine Iwate Medical University  Iwate Japan"},{"name":"Department of Geriatric and General Medicine The University of Osaka, Graduate School of Medicine  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4505-7951","authenticated-orcid":false,"given":"Yasuharu","family":"Tabara","sequence":"additional","affiliation":[{"name":"Graduate School of Public Health Shizuoka Graduate University of Public Health  Shizuoka Japan"},{"name":"Center for Genomic Medicine Kyoto University Graduate School of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Fukuma","sequence":"additional","affiliation":[{"name":"Department of Neurology National Cerebral and Cardiovascular Center  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7317-236X","authenticated-orcid":false,"given":"Yoshihisa","family":"Hiromine","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Metabolism and Diabetes Kindai University Faculty of Medicine  Osaka\u2010Sayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasunori","family":"Takata","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Molecular Genetics Ehime University Graduate School of Medicine  Toon Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Fukuda Clinic  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Katsuya","sequence":"additional","affiliation":[{"name":"Katsuya Clinic  Amagasaki 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