{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:49:55Z","timestamp":1791906595322,"version":"4.3.4"},"reference-count":50,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T00:00:00Z","timestamp":1760745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T00:00:00Z","timestamp":1760745600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["16H05277"],"award-info":[{"award-number":["16H05277"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      To investigate the impact of preoperative exercise and nutritional interventions on postoperative complications, physical function, and activities of daily living (\n                      <jats:styled-content style=\"fixed-case\">ADL<\/jats:styled-content>\n                      ) 1\u2009year postoperatively in frail older patients with gastrointestinal cancer.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This single\u2010center, randomized controlled trial enrolled 62 patients aged \u2265\u200970\u2009years scheduled to undergo elective surgery for gastrointestinal cancer with decreased grip strength or walking speed between October 2017 and December 2022. Participants were randomly assigned to control (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200933) and intervention (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200929) groups; the latter performed resistance exercises and consumed amino acid\u2010containing jelly daily at home for 14\u2009days. All participants were followed\u2010up for 1\u2009year.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After exclusion, 27 and 18 patients were enrolled in the control and intervention groups, respectively. The average age was 80.4\u2009years, and 37.8% were male. Postoperative complications were observed in 51.9% and 44.4% of the control and intervention groups, respectively (95% confidence interval [CI] 0.62\u20132.19), with postoperative delirium observed in 25.9% and 33.3%, respectively (95% CI 0.31\u20131.94). There were no significant inter\u2010group differences in grip strength, walking speed, or skeletal muscle index. However, the intervention group showed superior knee extension strength maintenance (preoperatively: 100.2%\u2009\u00b1\u200918.3% vs. 119.1%\u2009\u00b1\u200968.8%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.19; discharge: 86.7%\u2009\u00b1\u200922.0% vs. 119.3%\u2009\u00b1\u200972.0%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.044), and lower rates of decreased ADLs or death 1\u2009year postoperatively (42.3% vs. 23.5%; RR 0.56, 95% CI 0.08\u20131.92).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This 14\u2010day preoperative exercise and nutritional intervention program did not significantly reduce postoperative complications in frail older patients with gastrointestinal cancer; however, it aided in maintaining knee extension strength at discharge.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ggi.70226","type":"journal-article","created":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T13:42:25Z","timestamp":1760794945000},"page":"1765-1773","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Pre\u2010Operative Resistance Training and Amino Acid Supplementation in Frail Patients With Gastrointestinal Cancer: A Randomized Clinical Trial"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2503-3921","authenticated-orcid":false,"given":"Taku","family":"Fujimoto","sequence":"first","affiliation":[{"name":"Department of Geriatric and General Medicine The University of Osaka Graduate School of Medicine  Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Akasaka","sequence":"additional","affiliation":[{"name":"Department of Geriatric and General Medicine The 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