{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T07:42:21Z","timestamp":1786174941355,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["25AA1001"],"award-info":[{"award-number":["25AA1001"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006559","name":"University of Tsukuba","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006559","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>We examined the association between the use of fall\u2010risk\u2010increasing drugs (FRIDs) and other medications, and the risk of fall\u2010related fractures in Japanese community\u2010dwelling older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used linked medical and long\u2010term care insurance claims data from Tsukuba City, Japan (2014\u20132019). Two designs were applied: a nested case\u2010control study comparing 1957 fracture cases to 7828 matched controls for long term use, and a case\u2010crossover (CCO) study for short term use including 1840 fracture cases with up to 180\u2009days of follow\u2010up, in which the case period (1\u201330\u2009days prior to the index date) was compared with control periods (five 30\u2010day periods up to 180\u2009days prior). Medication exposure included FRIDs and other medications. The outcome was non\u2010vertebral fractures defined by diagnostic codes, imaging, and surgical or procedural treatment. Conditional logistic regression was used to calculate odds ratios (ORs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the nested case\u2010control study, the adjusted ORs (fracture cases vs. controls) for use of calcium channel blockers (1.16, 95% confidence interval [CI]: 1.05\u20131.33) and other anti\u2010dementia drugs (1.62, 95% CI: 1.11\u20132.37) were significantly elevated. In the CCO study, the unadjusted ORs (case period vs. control periods) for antipsychotics (3.65, 95% CI: 1.78\u20137.49), opioids (1.53, 95% CI: 1.05\u20132.22), anticonvulsants (1.86, 95% CI: 1.15\u20132.99), and NSAIDs (1.46, 95% CI: 1.18\u20131.71) were significantly elevated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Long\u2010 and short\u2010term use of specific medications is associated with increased fracture risk in older adults. Therefore, attention should be paid to prescription of these drugs in older adults.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ggi.70243","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T08:58:34Z","timestamp":1763369914000},"page":"1799-1811","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Exploring Fall\u2010Related Fracture Risk by Possible Fall\u2010Risk Increasing Drugs in Japanese Older Adults Using Municipal Linked Medical and Long\u2010Term Care Claim Data: A Nested Case\u2010Control and Case\u2010Crossover Study"],"prefix":"10.1111","volume":"25","author":[{"given":"Hiroya","family":"Nakano","sequence":"first","affiliation":[{"name":"Department of Health Services Research, Graduate School of Comprehensive Human Sciences University of Tsukuba  Tsukuba Ibaraki 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