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Although its prevalence is higher than that of age\u2010related sarcopenia, the clinical recognition and structured management of this condition remain limited. In this narrative review, the pathophysiology of HAS is synthesized, the effectiveness of acute\u2010phase interventions is evaluated, and the implementation challenges are examined to propose multifaceted strategies for optimizing treatment outcomes. The development of HAS involves a vicious cycle of activity limitation, inflammation, malnutrition, and iatrogenic stress. Initiating interventions within 48\u2009h may aid in preserving muscle function and improving the patients' quality of life. However, protocol variability, inadequate patient stratification, fragile transitional care systems, and other challenges persist. The proposed solutions include modular protocols, electronic medical record\u2010integrated adaptive algorithms, and strengthened team coordination. To prevent HAS progression and improve patient\u2010centered outcomes, timely, structured multidisciplinary interventions in the acute phase are imperative. Standardized evaluations, scalable protocols, and sustainable post\u2010discharge systems are key to advancing the clinical implementation of HAS management strategies.<\/jats:p>","DOI":"10.1111\/ggi.70330","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T07:26:31Z","timestamp":1769066791000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Acute\u2010Phase Interventions and Clinical Implementation Challenges for Hospital\u2010Associated Sarcopenia: A Narrative Review of a Multifaceted Approach to a Preventable Condition"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0990-0825","authenticated-orcid":false,"given":"Yoshinori","family":"Yamamoto","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine Mie University Graduate School of Medicine  Tsu Mie Japan"},{"name":"Department of Rehabilitation Mie University 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