{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T15:33:38Z","timestamp":1793028818482,"version":"4.5.0"},"reference-count":77,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Currently, frailty has become a central issue in health management among middle\u2010aged and older people living with HIV\/AIDS (PLWHA) worldwide. The objective is to develop targeted strategies to improve frailty in this group, enhance their long\u2010term quality of life, and advance the management of chronic diseases in healthcare settings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive computer\u2010based search was conducted across 11 databases to identify observational studies that reported the prevalence or influencing factors of frailty among middle\u2010aged and older PLWHA. The search period spanned from the database's inception to August 19, 2025. The meta\u2010analysis of the overall prevalence of frailty and associated factors was performed using Stata 17.0 and RevMan 5.4, respectively. Two independent researchers assessed the risk of bias using the Agency for Healthcare Research and Quality (AHRQ) and the Newcastle\u2010Ottawa scale (NOS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>This study screened 43 studies from 2040 publications. The meta\u2010analysis revealed an overall prevalence of frailty among middle\u2010aged and older PLWHA of 12%. Factors significantly associated with frailty in this population included age\u2009\u2265\u200960\u2009years, single, widowed, or divorced, low educational level, history of tobacco use, \u2265\u20091 comorbidities, diabetes, hepatitis, renal disease, osteoporosis, sleep disorders, neurocognitive impairment, cardiovascular disease, presence of depressive symptoms, and current CD4 cell count &lt;\u2009200\u2009cells\/\u03bcL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Based on the evidence generated by this study, frailty management should be prioritized among PLWHA to support the transition of AIDS from a life\u2010threatening disease to a manageable chronic condition, ultimately achieving the goal of enabling patients to live with quality and dignity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ggi.70341","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T12:25:31Z","timestamp":1770380731000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Prevalence and Influencing Factors of Frailty Among Middle\u2010Aged and Older Adults With\n                    <scp>HIV<\/scp>\n                    \/\n                    <scp>AIDS<\/scp>\n                    From a Global Perspective: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7378-325X","authenticated-orcid":false,"given":"Yuelin","family":"Wang","sequence":"first","affiliation":[{"name":"College of Nursing Chengdu University of Traditional Chinese Medicine  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunlan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Party Committee Office Hospital of Chengdu University of Traditional Chinese Medicine  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Li","sequence":"additional","affiliation":[{"name":"College of Nursing Chengdu University of Traditional Chinese Medicine  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Nursing Chengdu University of Traditional Chinese Medicine  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Nursing Chengdu University of Traditional Chinese Medicine  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengjie","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Nursing Chengdu University of Traditional Chinese Medicine  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Bai","sequence":"additional","affiliation":[{"name":"College of Nursing Chengdu University of Traditional Chinese Medicine  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senlin","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Nursing Chengdu University of Traditional Chinese Medicine  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,6]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.2991\/jegh.k.210621.001"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2023.1068664"},{"key":"e_1_2_12_4_1","unstructured":"Unaids Global HIV&AIDS Statistics: Fact Sheet [EB\/OL]. 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