{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T02:20:21Z","timestamp":1789006821735,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Frailty syndrome is a common age\u2010related condition associated with increased risks of disability, hospitalization, and mortality. Although physical activity (PA) is a modifiable lifestyle factor, limited research has explored how specific PA domains relate to frailty using validated multidimensional models. This study aimed to examine the associations between 4 PA domains\u2014total PA, occupational PA (OPA), transport\u2010related PA (TPA), and leisure\u2010time PA (LTPA)\u2014and frailty syndrome, as assessed by both the frailty phenotype (FP) and frailty index (FI) models in a nationally representative U.S. sample.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed data from 59\u2009842 adults who participated in 6 cycles of the National Health and Nutrition Examination Survey (NHANES, 2007\u20132018). PA levels were self\u2010reported and categorized by weekly duration based on guideline adherence (\u2265\u2009150\u2009min\/week) and distribution quartiles. Frailty was independently assessed using FP and FI models. Multivariable linear regression, subgroup, sensitivity analysis, and dose\u2013response analyses were conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Higher levels of total PA and LTPA were consistently associated with lower frailty scores in both FP and FI models. The strongest inverse associations were observed for LTPA \u2265\u2009300\u2009min\/week. In contrast, OPA and TPA showed limited or no associations after adjustment for confounders. Subgroup and sensitivity analyses supported these findings, with particularly pronounced effects among older adults (\u2265\u200980\u2009years) and women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>LTPA demonstrated the strongest associations with lower frailty, highlighting its potential as a key target for preventive strategies and public health guidelines aimed at promoting healthy aging.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ggi.70384","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T04:17:13Z","timestamp":1770265033000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Domain\u2010Specific Physical Activity and Its Association With Frailty Syndrome: Evidence From\n                    <scp>NHANES<\/scp>\n                    Using Phenotype and Index\u2010Based Models"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5472-7569","authenticated-orcid":false,"given":"Fujue","family":"Ji","sequence":"first","affiliation":[{"name":"Department of Physical Education, College of Performing Arts and Sport Hanyang University  Seoul Republic of Korea"},{"name":"BK21 FOUR Human\u2010Tech Convergence Program Hanyang University  Seoul Republic of Korea"},{"name":"Aging and Aged Laboratory Hanyang University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Physical Education, College of Performing Arts and Sport Hanyang University  Seoul Republic of Korea"},{"name":"Aging and Aged Laboratory Hanyang University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Physical Education, College of Performing Arts and Sport Hanyang University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeonseung","family":"Rheem","sequence":"additional","affiliation":[{"name":"Department of Physical Education, College of Performing Arts and Sport Hanyang University  Seoul Republic of Korea"},{"name":"BK21 FOUR Human\u2010Tech Convergence Program Hanyang University  Seoul Republic of Korea"},{"name":"Aging and Aged Laboratory Hanyang University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haesung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Physical Education, College of Performing Arts and Sport Hanyang University  Seoul Republic of Korea"},{"name":"BK21 FOUR Human\u2010Tech Convergence 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