{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T15:52:25Z","timestamp":1779897145822,"version":"3.53.1"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T00:00:00Z","timestamp":1771113600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["23FA1006"],"award-info":[{"award-number":["23FA1006"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K19663"],"award-info":[{"award-number":["22K19663"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23K24609"],"award-info":[{"award-number":["23K24609"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25H01090"],"award-info":[{"award-number":["25H01090"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Evidence regarding the association between heart failure and sarcopenia in middle\u2010aged and older community\u2010dwelling adults is scarce. This study aimed to examine the association between NT\u2010proBNP levels and sarcopenia among community\u2010dwelling adults aged 40\u201374\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross\u2010sectional study was conducted based on the Circulatory Risk in Communities Study, which involved 1675 Japanese residents aged 40\u201374\u2009years. Serum N\u2010terminal pro\u2010brain natriuretic peptide (NT\u2010proBNP) levels, physical function, and lifestyle information were measured. Participants were categorized according to their NT\u2010proBNP levels (&lt;\u200955, 55\u2013124, and \u2265\u2009125\u2009pg\/mL). Multivariate\u2010adjusted logistic regression models were used to calculate the odds ratios for low skeletal muscle mass, muscle strength, walking speed, maximal walking speed, and sarcopenia according to serum NT\u2010proBNP levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the analyzed participants, the prevalence was 22.6% for low skeletal muscle mass, 4.3% for low handgrip strength, 14.3% for low walking speed, 24.1% for low maximal walking speed, and 5.9% for sarcopenia. The multivariable odds ratios (95% confidence interval, p for trend) comparing the highest versus lowest groups of serum NT\u2010proBNP levels were 1.63 (1.07\u20132.49,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01) for low skeletal muscle mass, 3.38 (1.70\u20136.73,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01) for low handgrip strength, 1.81 (0.96\u20133.40,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.06) for low walking speed, 1.75 (1.03\u20132.97,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.06) for low maximal walking speed, and 2.56 (1.07\u20136.14,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03) for sarcopenia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>High serum NT\u2010proBNP levels, which are a surrogate marker for heart failure, were associated with low physical function and sarcopenia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ggi.70404","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:59:50Z","timestamp":1771203590000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Associations Between Serum\n                    <scp>N<\/scp>\n                    \u2010Terminal Pro\u2010Brain Natriuretic Peptide Levels and the Prevalence of Sarcopenia\u00a0in Middle\u2010Aged and Older\n                    <scp>J<\/scp>\n                    apanese Adults: A\u00a0Population\u2010Based Cross\u2010Sectional Study"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-3152-8340","authenticated-orcid":false,"given":"Ren","family":"Sato","sequence":"first","affiliation":[{"name":"Doctoral Program in Public Health, Graduate School of Comprehensive Human Sciences University of Tsukuba  Tsukuba Japan"},{"name":"Department of Public Health Medicine, Institute of Medicine, and Health Services Research Center University of Tsukuba  Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazumasa","family":"Yamagishi","sequence":"additional","affiliation":[{"name":"Department of Public Health Medicine, Institute of Medicine, and Health Services Research Center University of Tsukuba  Tsukuba Japan"},{"name":"Department of Public Health, Graduate School of Medicine Juntendo University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshige","family":"Jinnouchi","sequence":"additional","affiliation":[{"name":"Department of Public Health Medicine, Institute of Medicine, and Health Services Research Center University of Tsukuba  Tsukuba Japan"},{"name":"Faculty of Medicine, Department of Hygiene and Public Health Nippon Medical School  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isao","family":"Muraki","sequence":"additional","affiliation":[{"name":"Department of Public Health Medicine, Institute of Medicine, and Health Services Research Center University of Tsukuba  Tsukuba Japan"},{"name":"Ibaraki Western Medical Center  Chikusei Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikako","family":"Yasuoka","sequence":"additional","affiliation":[{"name":"Department of Public Health Medicine, Institute of Medicine, and Health Services Research Center University of Tsukuba  Tsukuba Japan"},{"name":"Department of Public Health, Graduate School of Medicine Juntendo University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hironobu","family":"Kakihana","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, Faculty of Rehabilitation Kobe Gakuin University  Kobe Japan"},{"name":"Department of Public Health Kindai University Faculty of Medicine  Sakai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachimi","family":"Kubo","sequence":"additional","affiliation":[{"name":"Department of Public Health Kindai University Faculty of Medicine  Sakai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomomi","family":"Kihara","sequence":"additional","affiliation":[{"name":"Department of Public Health Medicine, Institute of Medicine, and Health Services Research Center University of Tsukuba  Tsukuba Japan"},{"name":"Division of Public Health, Department of Planning and 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