{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T21:47:58Z","timestamp":1773006478216,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K11809"],"award-info":[{"award-number":["22K11809"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Pyridoxal 5\u2032\u2010phosphate (PLP) is the coenzyme form of vitamin B\n                      <jats:sub>6<\/jats:sub>\n                      . PLP is essential for amino acid metabolism, protein turnover, and neurotransmitter synthesis. Plasma or serum PLP concentration is used as an indicator of vitamin B\n                      <jats:sub>6<\/jats:sub>\n                      status. A deficiency in PLP may be a risk factor for frailty. While previous cross\u2010sectional studies have associated low plasma or serum PLP levels with frailty, this association has not yet been examined in older Japanese adults.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed data from 419 community\u2010dwelling individuals aged \u2265\u200965\u2009years in Tarumizu City, Kagoshima, Japan. Participants with relevant medical histories, missing data, or extreme values were excluded. Frailty was assessed using J\u2010CHS criteria. Serum PLP concentrations were divided into quartiles (Q1\u2013Q4). Logistic regression was used to estimate the Odds ratios (ORs) for pre\u2010frailty\/frailty after adjusting for demographic, lifestyle, and clinical factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Pre\u2010frailty\/frailty prevalence was 62%, 40%, 57%, and 57% in Q1\u2013Q4, respectively. The proportion of pre\u2010frailty\/frailty was the lowest in Q2. Compared to Q2, adjusted ORs were 1.94 (95% CI: 1.06\u20133.59;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.033) in Q1, 1.68 (95% CI: 0.93\u20133.07;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.089) in Q3, and 1.86 (95% CI: 1.01\u20133.47;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.047) in Q4.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The relationship between PLP levels and pre\u2010frailty\/frailty was found to be non\u2010linear. The lowest prevalence was observed in Q2, whereas both low and high PLP levels were associated with increased ORs of pre\u2010frailty\/frailty. Further prospective studies are needed to clarify the causal relationship in older Japanese adults.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ggi.70412","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T08:58:29Z","timestamp":1771491509000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Serum Pyridoxal 5\u2032\u2010Phosphate and Frailty Risk in Community\u2010Dwelling Older Japanese Adults"],"prefix":"10.1111","volume":"26","author":[{"given":"Maika","family":"Ohta","sequence":"first","affiliation":[{"name":"Department of Nutrition, Graduate School of Human Life and Ecology Osaka Metropolitan University  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaori","family":"Kaimoto","sequence":"additional","affiliation":[{"name":"Department of Human Life and Science Kagoshima Women's College  Kagoshima 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