{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T03:36:43Z","timestamp":1785901003652,"version":"3.56.0"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K15701"],"award-info":[{"award-number":["22K15701"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K19500"],"award-info":[{"award-number":["22K19500"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25K19008"],"award-info":[{"award-number":["25K19008"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25K24185"],"award-info":[{"award-number":["25K24185"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Identifying high\u2010risk individuals for future cognitive decline is key for timely and efficient interventions against dementia. Although imaging and biofluid biomarkers have been developed to detect neuropathological changes and predict future disease progression, their high costs and low accessibility limit their widespread use. We previously developed an eye\u2010tracking\u2010based cognitive assessment (ETCA) as a novel screening tool for dementia and demonstrated its utility in detecting mild cognitive decline with high accuracy. This study aimed to investigate the ETCA's performance in predicting future cognitive decline in a community\u2010based longitudinal study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Community\u2010dwelling older adults (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200955, mean age: 57.8 (SD, 12.6) years) without a formal diagnosis of dementia were enrolled and underwent the ETCA and neuropsychological tests, including the Mini\u2010Mental State Examination (MMSE), Addenbrooke's Cognitive Examination\u2010III (ACE\u2010III), and Rivermead Behavioral Memory Test (RBMT), both at baseline and at a 2\u2010year follow\u2010up point.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Approximately half (54.5%, 35\/55) of participants showed a decline in RBMT scores during the 2\u2010year follow\u2010up and were defined as the memory decline group. The baseline ETCA scores were significantly lower in the memory decline group than in the memory stable group. The baseline ETCA composite subscores achieved an AUC\u2010ROC of 0.709 in detecting future memory decline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The ETCA offers a rapid, objective, and low\u2010burden approach for screening for the risk of future cognitive decline, which could make a substantial contribution to the prevention of dementia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ggi.70439","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T05:10:11Z","timestamp":1773205811000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Eye\u2010Tracking\u2010Based Cognitive Assessment Predicts the Risk of Memory Decline: A Community\u2010Based Cohort Study"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2793-081X","authenticated-orcid":false,"given":"Mizuki","family":"Katsuhisa","sequence":"first","affiliation":[{"name":"Osaka Psychiatric Research Center, Osaka Psychiatric Medical Center  Hirakata Osaka Japan"},{"name":"Department of Clinical Gene Therapy, Graduate School of Medicine Osaka University  Suita Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin","family":"Teshirogi","sequence":"additional","affiliation":[{"name":"Osaka Psychiatric Research Center, Osaka Psychiatric Medical Center  Hirakata Osaka Japan"},{"name":"Department of Geriatric and General Medicine, Graduate School of Medicine Osaka University  Suita Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sho","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Osaka Psychiatric Research Center, Osaka Psychiatric Medical Center  Hirakata Osaka Japan"},{"name":"Department of Geriatric and General Medicine, Graduate School of Medicine Osaka University  Suita Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akane","family":"Oyama","sequence":"additional","affiliation":[{"name":"Osaka Psychiatric Research Center, Osaka Psychiatric Medical Center  Hirakata Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Ito","sequence":"additional","affiliation":[{"name":"Osaka Psychiatric Research Center, Osaka Psychiatric Medical Center  Hirakata Osaka Japan"},{"name":"Department of Clinical Gene Therapy, Graduate School of Medicine Osaka University  Suita Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuya","family":"Ikegawa","sequence":"additional","affiliation":[{"name":"Osaka Psychiatric Research Center, Osaka Psychiatric Medical Center  Hirakata Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Momoko","family":"Okawara","sequence":"additional","affiliation":[{"name":"Osaka Psychiatric Research Center, Osaka Psychiatric Medical Center  Hirakata Osaka Japan"},{"name":"Department of Geriatric and General Medicine, Graduate School of Medicine Osaka University  Suita Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuneo","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Osaka Psychiatric Research Center, Osaka Psychiatric Medical Center  Hirakata Osaka Japan"},{"name":"Department of Geriatric and General Medicine, Graduate School of Medicine Osaka University  Suita Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitaka","family":"Nakatani","sequence":"additional","affiliation":[{"name":"Osaka Psychiatric Research Center, Osaka Psychiatric Medical Center  Hirakata Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromi","family":"Bando","sequence":"additional","affiliation":[{"name":"Osaka Psychiatric Research Center, Osaka Psychiatric Medical Center  Hirakata Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayaka","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Osaka Psychiatric Research Center, Osaka Psychiatric Medical Center  Hirakata Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamoru","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Osaka Psychiatric Research Center, Osaka Psychiatric Medical Center  Hirakata Osaka Japan"},{"name":"Department of Neuropsychiatry Kindai University Faculty of Medicine  Sayama Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Iwata","sequence":"additional","affiliation":[{"name":"Osaka Psychiatric Research Center, Osaka Psychiatric Medical Center  Hirakata Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5258-1981","authenticated-orcid":false,"given":"Shuko","family":"Takeda","sequence":"additional","affiliation":[{"name":"Osaka Psychiatric Research Center, Osaka Psychiatric Medical Center  Hirakata Osaka Japan"},{"name":"Department of Clinical Gene Therapy, Graduate School of Medicine Osaka University  Suita Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,10]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852918001347"},{"issue":"6","key":"e_1_2_12_3_1","first-page":"9","article-title":"Mild Cognitive Impairment and Preclinical Alzheimer's Disease","author":"Morris J. C.","year":"2005","journal-title":"Geriatrics"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)01296-0"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30367-6"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-023-00410-4"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-021-03495-6"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181c34b47"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/S104161020700542X"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-019-1120-4"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/11038128.2010.528789"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2008.04.014"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101506"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-6576.2001.045003275.x"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14537"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000201572"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02391-8"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41746\u2010019\u20100084\u20102"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000541235"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-49275-x"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357\u2010025\u201001941\u2010x"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S151253"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/01688638908400940"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-018-0097-2"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-02368-x"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13229-016-0083-y"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-025-00874-5"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101491"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2011.05.005"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2024.1390574"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-02049-x"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2022.2379"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1159\/000355556"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-025-03565-2"}],"container-title":["Geriatrics &amp; Gerontology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ggi.70439","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ggi.70439","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ggi.70439","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T03:25:36Z","timestamp":1774495536000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ggi.70439"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1111\/ggi.70439"],"URL":"https:\/\/doi.org\/10.1111\/ggi.70439","archive":["Portico"],"relation":{},"ISSN":["1444-1586","1447-0594"],"issn-type":[{"value":"1444-1586","type":"print"},{"value":"1447-0594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"2025-11-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70439"}}