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However, no genetic association studies on white\u2010matter hyperintensities (WMH) have focused specifically on the Han Chinese population. Despite previous studies on candidate genes, none have explored association with glucose regulation. This study aimed to investigate the association between a genetic risk score (GRS) derived from glucose\u2010related loci and cerebrovascular abnormality, cerebral WMH, and brain microstructure markers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study is a community\u2010based family research conducted on 345 participants aged 65\u2009years and over who provided brain magnetic resonance imaging (MRI) examinations and genome\u2010wide association studies data. The volume of white\u2010matter lesions was measured using brain MRI. Generalized linear models with generalized estimating equations were used to analyze the associations between GRSs and brain MRI parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Based on the 194 glucose\u2010associated single\u2010nucleotide polymorphisms (SNPs), the GRSs for cerebrovascular abnormality, WMH volume, and fractional anisotropy (FA) and mean diffusivity (MD) for four brain regions, namely, the right and left corticospinal tracts and the cingulate gyri, were calculated based on 3, 3, 10, 5, 8, 6, 8, 8, 9, and 6 significant SNPs. After multivariable adjustment, unweighted and weighted GRS were both associated with cerebrovascular abnormality, WMH volume, FA, and MD of the four sites (right and left corticospinal tracts and cingulate gyri) except for the MD measured using the left cingulate gyrus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study indicated that glucose regulation\u2010associated loci are linked to MRI measures, which may provide novel insights into the presence and progression of brain injury.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ggi.70450","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T05:49:37Z","timestamp":1773208177000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Glucose\u2010Related Genetic Risk Score and Its Association With Cerebrovascular Abnormality, White\u2010Matter Hyperintensity Volume, and Brain Microstructure Markers"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9625-6216","authenticated-orcid":false,"given":"Cheng\u2010Chieh","family":"Lin","sequence":"first","affiliation":[{"name":"School of Medicine, College of Medicine China Medical University  Taichung Taiwan"},{"name":"Department of Medical Research China Medical University Hospital  Taichung Taiwan"},{"name":"Department of Family Medicine China Medical University Hospital  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia\u2010Ing","family":"Li","sequence":"additional","affiliation":[{"name":"School of Medicine, College of Medicine China Medical University  Taichung Taiwan"},{"name":"Department of Medical Research China Medical University Hospital  Taichung 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