{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T12:29:30Z","timestamp":1778848170512,"version":"3.51.4"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Emerging evidence suggests that alterations in gut microbiota composition may contribute to the onset and progression of sarcopenia through mechanisms involving systemic inflammation, metabolic dysregulation, and reduced production of short\u2010chain fatty acids (SCFAs). However, data from Indian older adults\u2014who exhibit diverse diets and microbiota profiles\u2014are lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This hospital\u2010based cross\u2010sectional pilot study enrolled 30 older adults aged \u2265\u200960\u2009years, including 15 with sarcopenic and 15 age\u2010 and sex\u2010matched nonsarcopenic. Sarcopenia was classified according to the Asian Working Group for Sarcopenia (AWGS\u20102019) criteria. Stool samples were analyzed using 16S ribosomal RNA (rRNA) sequencing (V3\u2013V4 region, Illumina MiSeq). Taxonomic classification and diversity indices (Chao1, Shannon, UniFrac) were compared between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The mean age (S.D.) of study participants was 73.27\u2009\u00b1\u20095.96\u2009years. A total of 251\u2009315 high\u2010quality sequences were generated from 30 fresh human fecal samples. The dominant phylum in the nonsarcopenic group was Firmicutes (41.2%), followed by Bacteroidetes (36.0%), whereas in the sarcopenic group, Bacteroidetes (39.2%) was most common, followed by Firmicutes (37.8%). A decrease in Operational Taxonomic Units (OTUs) of genus Bifidobacterium (2.21% vs. 3.71%), Bacteroides (8.50% vs. 11.11%) was observed in the sarcopenic group. An increase in OTUs of genus Faecalibacterium (10.64% vs. 8.23%) in the sarcopenic group was observed. The alpha\u2010diversity index Chao1, Shannon was reduced in sarcopenic population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Exploratory differences in microbial diversity and relative abundance were observed between sarcopenic and nonsarcopenic older adults. These findings are descriptive and hypothesis\u2010generating and warrant confirmation in larger, adequately powered studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ggi.70500","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T01:40:48Z","timestamp":1776822048000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Gut Microbiota Signatures of Sarcopenia: A Comparative\n                    <scp>16S rRNA<\/scp>\n                    Sequencing Study in Older Indian Adults"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9218-748X","authenticated-orcid":false,"given":"Sudeep Mathew","family":"George","sequence":"first","affiliation":[{"name":"Department of Geriatric Medicine, National Centre for Ageing All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prasun","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, National Centre for Ageing All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rama","family":"Chaudhry","sequence":"additional","affiliation":[{"name":"Department of Microbiology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vishwa Deepak","family":"Bamola","sequence":"additional","affiliation":[{"name":"Department of Microbiology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maroof Ahmad","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Biostatistics All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayushi","family":"Purohit","sequence":"additional","affiliation":[{"name":"Artemis Education and Research Foundation (AERF), Artemis Hospitals  Gurugram Haryana India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2093-7039","authenticated-orcid":false,"given":"Varun","family":"Suroliya","sequence":"additional","affiliation":[{"name":"Artemis Education and Research Foundation (AERF), Artemis Hospitals  Gurugram Haryana India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramaa","family":"Muley","sequence":"additional","affiliation":[{"name":"Indian Institute of Science, Education and Research (IISER)  Bhopal Madhya Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7651-898X","authenticated-orcid":false,"given":"Avinash","family":"Chakrawarty","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, National Centre for Ageing All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,21]]},"reference":[{"key":"e_1_2_15_2_1","volume-title":"World Population Ageing 2019: Highlights","author":"United Nations Department of Economic and Social Affairs, Population Division","year":"2019"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afy169"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a025700"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11010160"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0169548"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12051293"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877\u2010018\u20100878\u20100"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01385"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aac8469"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9121303"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.05.041"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10101403"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.00660"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010022\u201007477\u20109"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2013.05.018"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2019.12.012"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2018.04.015"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.11604\/pamj.2024.48.80.42997"},{"key":"e_1_2_15_20_1","first-page":"61","article-title":"Functional Evaluation: The Barthel Index","volume":"14","author":"Mahoney F. 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