{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T10:18:14Z","timestamp":1780568294387,"version":"3.54.1"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP25gm2110001"],"award-info":[{"award-number":["JP25gm2110001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100030953","name":"Tokyo Metropolitan Institute for Geriatrics and Gerontology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100030953","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study examined the association between plasma pentosidine concentrations\u2014an advanced glycation end\u2010product marker\u2014and skeletal muscle morphometric indices, physical function, and sarcopenia among community\u2010dwelling older adults without diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross\u2010sectional study analyzed data from the 2023 Itabashi Longitudinal Study on Aging in Itabashi Ward, Tokyo, Japan. Participants aged \u2265\u200970\u2009years were included. Associations between pentosidine concentrations and skeletal muscle morphometric indices and physical function were examined using multiple linear regression adjusted for age, sex, and estimated glomerular filtration rate (eGFR). To explore sex differences, pentosidine \u00d7 sex interaction terms were tested. Multivariable logistic regression with the same covariates examined associations with impaired physical function, sarcopenia, and severe sarcopenia defined by the Asian Working Group for Sarcopenia 2019 criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 424 participants (mean age 75.7\u2009years; 48.3% women), the mean plasma pentosidine concentration was 5.59\u2009\u03bcg\u2009\u00d7\u200910\n                      <jats:sup>\u22122<\/jats:sup>\n                      \/mL, with no sex difference. In quartile\u2010based analyses adjusted for age and eGFR, higher pentosidine concentrations were associated with lower skeletal muscle mass index (SMI) and slower gait speed in women, but not in men. In multivariable analyses adjusted for age, sex, and eGFR, higher pentosidine concentrations were independently associated with lower SMI, lower whole\u2010body and limb phase angles, and lower short physical performance battery scores. Pentosidine levels were not significantly associated with grip strength, chair rise performance, sarcopenia, or severe sarcopenia. No significant pentosidine \u00d7 sex interactions were observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Higher plasma pentosidine concentrations were associated with lower skeletal muscle mass and unfavorable muscle\u2010related indices in older adults without diabetes. Although stratified analyses suggested stronger associations in women, interaction testing did not support significant sex\u2010specific effects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ggi.70515","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T07:20:17Z","timestamp":1778484017000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association Between Plasma Pentosidine and Skeletal Muscle\u2010Related Indices in Older Adults Without Diabetes"],"prefix":"10.1111","volume":"26","author":[{"given":"Takashi","family":"Shida","sequence":"first","affiliation":[{"name":"Research Team for Promoting Independence and Mental Health Tokyo Metropolitan Institute for Geriatrics and Gerontology  Tokyo 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